Paper Report for: Zhang_2022_Biotechnol.Appl.Biochem__
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Title: Bioactivity of hamamelitannin, flavokawain A, and triacetyl resveratrol as natural compounds: Molecular docking study, anti-colon cancer and anti-Alzheimer potentials Zhang M, Xue J, Chen X, Elsaid FG, Salem ET, Ghanem RA, El-Kott AF, Xu Z Ref: Biotechnol Appl Biochem, :, 2022 : PubMed
In this study, we worked on anti-colon cancer effects and anti-Alzheimer's disease with molecular docking studies. Hamamelitannin, Flavokawain A, Triacetyl resveratrol compounds showed good inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. For obtaining the inhibition effects of flavokawain A, hamamelitannin, and triacetyl resveratrol on AChE and BuChE enzymes were determined spectrophotometrically conforming to Ellman. IC(50) values of these enzymes were ranging between 0.95+/-0.12 to 93.27+/-8.14 nM for AChE and 5.71+/-0.77 to 52.10+/-8.41 nM for BuChE. The inhibitory activities of some chemical compounds such as flavokawain A, hamamelitannin, and triacetyl resveratrol were assessed by performing the molecular docking study in the presence of AChE and BChE. Also, about the features of the ligand-enzyme complex that had value of -7.722 kcal/mol for flavokawain A against AChE and -5.530 kcal/mol against BuChE. The molecular docking calculations indicated the probable interactions and their characteristics at an atomic level. Due to the outcomes gained from docking, the affinity of the chemical compounds to the enzymes was considerable. In vitro cell viabilities of Flavokawain A, Hamamelitannin, Triacetyl resveratrol with various concentrations on SW620, DLD-1, HT29, HCT8, and HCT116 were investigated by MTT assay with Dox (Doxorubicin) as the control compound. This article is protected by copyright. All rights reserved.
        
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Zhang M, Xue J, Chen X, Elsaid FG, Salem ET, Ghanem RA, El-Kott AF, Xu Z (2022) Bioactivity of hamamelitannin, flavokawain A, and triacetyl resveratrol as natural compounds: Molecular docking study, anti-colon cancer and anti-Alzheimer potentials Biotechnol Appl Biochem
Zhang M, Xue J, Chen X, Elsaid FG, Salem ET, Ghanem RA, El-Kott AF, Xu Z (2022) Biotechnol Appl Biochem