Paper Report for: Zheng_2005_Bioorg.Med.Chem.Lett_15_4463
Reference
Title: Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA Ref: Bioorganic & Medicinal Chemistry Lett, 15:4463, 2005 : PubMed
A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at alpha4beta2* and alpha7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivity for VMAT2.
        
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Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA (2005) Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands Bioorganic & Medicinal Chemistry Lett15: 4463-6