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Reactivator Report for: 7-MEOTA-4-pyridinealdoxime

General
Type Derivative of Tacrine, Acridine, Oxime, Pyridine
Chemical_Nomenclature
Canonical SMILES COC1=CC3=C(C=C1)N=C2CCCCC2C3NCCCCCN4C=CC(=C[N+]([H])=O)C=C4.[Br-]
InChI 1S/C25H32N4O2.BrH/c1-31-20-9-10-24-22(17-20)25(21-7-3-4-8-23(21)28-24)26-13-5-2-6-14-29-15-11-19(12-16-29)18-27-30;/h9-12,15-18,21,25-26H,2-8,13-14H2,1H3;1H
InChIKey RHZHDPUJVQCCPY-UHFFFAOYSA-N
Other name(s) 7-methoxytacrine-4-pyridinealdoxime
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MW|501.46
Formula|C25H33BrN4O2
CAS_number|
PubChem|
UniChem|RHZHDPUJVQCCPY-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: 7-MEOTA-4-pyridinealdoxime
    Title: Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach
    da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Franca TCC
    Ref: J Enzyme Inhib Med Chem, 34:1018, 2019 : PubMed

            

    Title: Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths
    da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Franca TCC
    Ref: Chemico-Biological Interactions, 307:195, 2019 : PubMed

            

    Title: A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
    Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L and Kuca K <3 more author(s)>
    Ref: Toxicol Res (Camb), 5:1012, 2016 : PubMed

            


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