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Reactivator Report for: GM508

toxic in lower micromolar concentrations


General
Type Oxime, Pyridine-aldoxime, Isoquinoline
Chemical_Nomenclature 6-(5-(1-(4-(Dimethylamino)phenyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)pentyl)-3-hydroxypicolinaldehyde oxime
Canonical SMILES C1(=C(N=C(C=C1)CCCCCN2C(C3=C(CC2)C=C(C(=C3)OC)OC)C4=CC=C(C=C4)N(C)C)C=NO)O
InChI InChI=1S/C30H38N4O4/c1-33(2)24-12-9-21(10-13-24)30-25-19-29(38-4)28(37-3)18-22(25)15-17-34(30)16-7-5-6-8-23-11-14-27(35)26(32-23)20-31-36/h9-14,18-20,30,35-36H,5-8,15-17H2,1-4H3
InChIKey ZTBJJQOFAUNMBC-UHFFFAOYSA-N
Other name(s)
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MW|519.65
Formula|C30H39N4O4
CAS_number|
PubChem|
UniChem|ZTBJJQOFAUNMBC-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: GM508
    Title: Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning
    Zorbaz T, Misetic P, Probst N, Zunec S, Zandona A, Mendas G, Micek V, Macek Hrvat N, Katalinic M and Kovarik Z <4 more author(s)>
    Ref: ACS Chem Neurosci, :, 2020 : PubMed

            

    Title: An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice
    Calas AG, Dias J, Rousseau C, Arboleas M, Touvrey-Loiodice M, Mercey G, Jean L, Renard PY, Nachon F
    Ref: Chemico-Biological Interactions, 267:11, 2017 : PubMed

            


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