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Reactivator Report for: K792

IC50 0.005 (5nM) Ki 0.4 muM human AChE, IC50 3.2 muM human BChE


General
Type Bispyridinium
Chemical_Nomenclature 1-(10-pyridin-1-ium-1-yldecyl)quinolin-1-ium;dibromide
Canonical SMILES C1=CC=[N+](C=C1)CCCCCCCCCC[N+]2=CC=CC3=CC=CC=C32.[Br-].[Br-]
InChI InChI=1S/C24H32N2.2BrH/c1(3-5-10-18-25-19-11-7-12-20-25)2-4-6-13-21-26-22-14-16-23-15-8-9-17-24(23)26;;/h7-9,11-12,14-17,19-20,22H,1-6,10,13,18,21H2;2*1H/q+2;;/p-2
InChIKey NONXEJNDQDZQHP-UHFFFAOYSA-L
Other name(s) CHEMBL3093802 ; BDBM50005115
________________________________________________________________________________________________
MW|508.34
Formula|C24H32Br2N2
CAS_number|
PubChem|72724911
UniChem|NONXEJNDQDZQHP-UHFFFAOYSA-L
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: K792
    Title: Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings
    Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M and Musilek K <4 more author(s)>
    Ref: Drug Des Devel Ther, 12:505, 2018 : PubMed

            

    Title: Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors
    Komloova M, Horova A, Hrabinova M, Jun D, Dolezal M, Vinsova J, Kuca K, Musilek K
    Ref: Bioorganic & Medicinal Chemistry Lett, 23:6663, 2013 : PubMed

            

    Title: Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment
    Komloova M, Musilek K, Horova A, Holas O, Dohnal V, Gunn-Moore F, Kuca K
    Ref: Bioorganic & Medicinal Chemistry Lett, 21:2505, 2011 : PubMed

            


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