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Reactivator Report for: RS194B

Un charged oxime that cross the blood-brain barrier


General
Type Uncharged Oxime, Oxime, Azepane
Chemical_Nomenclature N-[2-(azepan-1-yl)ethyl]-2-hydroxyiminoacetamide
Canonical SMILES C1CCCN(CC1)CCNC(=O)C=NO
InChI InChI=1S/C10H19N3O2/c14-10(9-12-15)11-5-8-13-6-3-1-2-4-7-13/h9,15H,1-8H2,(H,11,14)
InChIKey VIABFASHQHHYNB-UHFFFAOYSA-N
Other name(s) RS-194B ; AC1OAKUK ; Oprea1_728133 ; SCHEMBL15963820 ; MCULE-3450389482 ; 2-(Hydroxyimino)-iV-(2-(azepan-l-yl)ethyl)acetamide
________________________________________________________________________________________________
MW|214.5
Formula|C10H19N3O2
CAS_number|
PubChem|6831267
UniChem|VIABFASHQHHYNB-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Stucture | 2 structures: 6U34, 6U37

References:
Search PubMed for references concerning: RS194B

14 more
    Title: Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects
    Blumenthal DK, Cheng X, Fajer M, Ho KY, Rohrer J, Gerlits O, Taylor P, Juneja P, Kovalevsky A, Radic Z
    Ref: Journal of Biological Chemistry, :101007, 2021 : PubMed

            

    Title: Enhancing target tissue levels and diminishing plasma clearance of ionizing zwitterionic antidotes in organophosphate exposures
    Shyong YJ, Sepulveda Y, Garcia A, Samskey NM, Radic Z, Sit R, Sharpless KB, Momper JD, Taylor P
    Ref: Journal of Pharmacology & Experimental Therapeutics, :, 2021 : PubMed

            

    Title: Rational design, synthesis and evaluation of uncharged, smart bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase
    Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal DK, Taylor P, Ballatore C, Kovalevsky A, Radic Z
    Ref: Journal of Biological Chemistry, 295:4079, 2020 : PubMed

            


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