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Structure Report for: 5LZ7

NameFragment-based inhibitors of Lipoprotein associated Phospholipase A2
Revelation date21-Dec-2016
FamilyPAF-Acetylhydrolase: there are 149 genes in this family, 35 structure(s)
Gene_locushuman-PLA2G7
PDB FileESTHER: header of PDB entry RCSB: Full entry
CommentWoolford, A.J-A, Day, P.J.
Reference
    Title: Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)
    Woolford AJ, Day PJ, Beneton V, Berdini V, Coyle JE, Dudit Y, Grondin P, Huet P, Lee LY and Zhang X <11 more author(s)>
    Ref: Journal of Medicinal Chemistry, 59:10738, 2016 : PubMed

            

LigandInhibitor: CHEMBL3924430 Ligand in structure: Ligplot
Representative scheme of PAF-Acetylhydrolase structure and an image from PDBsum server
Databases
PDB-Sum5LZ7 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5LZ7 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5LZ7 Structural Classification Of Protein - SCOP server
PROTEOPEDIA5lz7 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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