6AVW

Name : Crystal structure of Arabidopsis thaliana protein deacetylase AtSOBER1 L63A mutant

Revelation date : 27-Dec-2017

Family : LYsophospholipase_carboxylesterase

Gene_locus : arath-SOBR1

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Burger et al.<\/A> show that Acyl-protein thioesterase structures present a long tunnel for accommodation of long-chain fatty acids and release the product by use of a flexible loop tunnel lid. Homologous deacetylases use a hydrophobic residue to fix the lid and another residue to close the tunnel entrance. This causes loop rigidity changing the catalytic preference to deacetylation. SOBER1 is a protein deacetylase and not an acylprotein thioesterase