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Structure Report for: 1K4Y

Name|Crystal Structure of Rabbit Liver Carboxylesterase in Complex with 4-piperidino-piperidine (leaving group of the hydrolysis of CPT11 to SN-38)
Revelation date|01-May-2002
Family|Carb_B_Chordata: there are 543 genes in this family, 21 structure(s)
Gene_locus|rabit-1cxes
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Ligand|Substrate: Irinotecan Ligand in structure: Ligplot Inhibitor: 4-piperidino-piperidine Ligand in structure: Ligplot


Reference

    Title: Structural insights into CPT-11 activation by mammalian carboxylesterases
    Bencharit S, Morton CL, Howard-Williams EL, Danks MK, Potter PM, Redinbo MR
    Ref: Nat Struct Biol, 9:337, 2002 : PubMed

            



Representative scheme of Carb_B_Chordata structure and an image from PDBsum server



Databases

PDB-Sum1K4Y Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP1K4Y Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP1K4Y Structural Classification Of Protein - SCOP server
PROTEOPEDIA1k4y 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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