2FJP
Name : Human dipeptidyl peptidase IV\/CD26 in complex with an inhibitor
Revelation date : 04-Jul-2006
Family : DPP4N_Peptidase_S9
Gene_locus : human-DPP4
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Edmondson, S.D., Mastracchio, A., Mathwink, R.J., He, J., Harper, B, Park, Y-J., Beconi, M., Di Salvo, J., Eirmann, G.J., He, H, Leiting, B., Leone, J.F., Levorse, D.A., Lyons, K., Patel, R.A., Patel, S.B., Petrov, A., Scapin, G., Shang, J., Roy, R.S., Sm
Ligand :
References (1)
| Title : (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]tr iazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Edmondson_2006_J.Med.Chem_49_3614 |
| Author(s) : Edmondson SD , Mastracchio A , Mathvink RJ , He J , Harper B , Park YJ , Beconi M , Di Salvo J , Eiermann GJ , He H , Leiting B , Leone JF , Levorse DA , Lyons K , Patel RA , Patel SB , Petrov A , Scapin G , Shang J , Roy RS , Smith A , Wu JK , Xu S , Zhu B , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 49 :3614 , 2006 |
| Abstract : Edmondson_2006_J.Med.Chem_49_3614 |
| ESTHER : Edmondson_2006_J.Med.Chem_49_3614 |
| PubMedSearch : Edmondson_2006_J.Med.Chem_49_3614 |
| PubMedID: 16759103 |
| Gene_locus related to this paper: human-DPP4 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
