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Structure Report for: 2RGU

Name|Crystal structure of complex of human DPP4 and (BI 1356): A Highly Potent, Selective, Long-Acting, and Orally Bioavailable inhibitor
Revelation date|06-Nov-2007
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 182 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Eckhardt, M., Langkopf, E., Mark, M., Taddayon, M., Thomas, L., Nar, H., Pfrengle, W., Guth, B., Lotz, R., Sieger, P., Fuchs, H., Himmelsbach, F.
Ligand|Inhibitor: Linagliptin Ligand in structure: Ligplot


    Title: 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylme thyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes
    Eckhardt M, Langkopf E, Mark M, Tadayyon M, Thomas L, Nar H, Pfrengle W, Guth B, Lotz R and Himmelsbach F <2 more author(s)>
    Ref: Journal of Medicinal Chemistry, 50:6450, 2007 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum2RGU Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP2RGU Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP2RGU Structural Classification Of Protein - SCOP server
PROTEOPEDIA2rgu 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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