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Structure Report for: 4A5S

Name|Crystal Structure of human DDP4 in complex with a novel heterocyclic DPP4 inhibitor
Revelation date|08-Feb-2012
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
Gene_locus|human-DPP4
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Ostermann, N., Kroemer, M., Zink, F., Gerhartz, B., Sutton, J.M., Clark, S.E., Dunsdon, S.J., Fenton, G., Fillmore, A., Harris, N.V., Higgs, C., Hurley, C.A., Krintel, S.L., MacKenzie, R.E., Duttaroy, A., Gangl, E., Maniara, W., Sedrani, R., Namoto, K., Sirockin, F., Trappe, J., Hassiepen, U., Baeschlin, D.K.
Ligand|Inhibitor: CHEMBL1951424 Ligand in structure: Ligplot


Reference

    Title: Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes.
    Sutton JM, Clark DE, Dunsdon SJ, Fenton G, Fillmore A, Harris NV, Higgs C, Hurley CA, Krintel SL and Baeschlin DK <11 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 22:1464, 2012 : PubMed

            



Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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Databases

PDB-Sum4A5S Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP4A5S Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP4A5S Structural Classification Of Protein - SCOP server
PROTEOPEDIA4a5s 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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