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Structure Report for: 4HAI

Name|Crystal structure of human soluble human epoxide hydrolase complexed with N-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide.
Revelation date|26-Dec-2012
Family|Epoxide_hydrolase: there are 1154 genes in this family, 155 structure(s)
Gene_locus|human-EPHX2
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Pecic, S., Pakhomova, S., Newcomer, M.E., Morisseau, C., Hammock, B.D., Zhu, Z., Deng, S.
Ligand|Inhibitor: CHEMBL469792 Ligand in structure: Ligplot


Reference

    Title: Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors
    Pecic S, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD, Zhu Z, Rinderspacher A, Deng SX
    Ref: Bioorganic & Medicinal Chemistry Lett, 23:417, 2013 : PubMed

            



Representative scheme of Epoxide_hydrolase structure and an image from PDBsum server

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Databases

PDB-Sum4HAI Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP4HAI Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP4HAI Structural Classification Of Protein - SCOP server
PROTEOPEDIA4hai 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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