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Structure Report for: 4TVK

Name|Torpedo californica Acetylcholinesterase in complex with a chlorotacrine-juglone hybrid inhibitor
Revelation date|08-Oct-2014
Family|ACHE: there are 538 genes in this family, 315 structure(s)
Gene_locus|torca-ACHE
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Pesaresi, A., Samez, S., Lamba, D.
Ligand|Inhibitor: Chlorotacrine-juglone Ligand in structure: Ligplot


Reference

    Title: Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects
    Nepovimova E, Uliassi E, Korabecny J, Pena-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V and Bolognesi ML <6 more author(s)>
    Ref: Journal of Medicinal Chemistry, 57:8576, 2014 : PubMed

            



Representative scheme of ACHE structure and an image from PDBsum server



Databases

PDB-Sum4TVK Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP4TVK Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP4TVK Structural Classification Of Protein - SCOP server
PROTEOPEDIA4tvk 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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