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Structure Report for: 4UUQ

Name|Crystal structure of human mono-glyceride lipase in complex with SAR127303
Revelation date|21-Jan-2015
Family|Monoglyceridelipase_lysophospholip: there are 1179 genes in this family, 26 structure(s)
Gene_locus|human-MGLL
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Griebel, G., Pichat, P., Beeske, S., Leroy, T., Redon, N., Francon, D., Bert, L., Even, L., Lopez-Grancha, M., Tolstykh, T., Sun, F., Yu, Q., Brittain, S., Arlt, H., He, T., Zhang, B., Wiederschain, D., Bertrand, T., Houtman, J., Rak, A., Vallee, F., Michot, N., Auge, F., Menet, V., Bergis, O.E., George, P., Avenet, P., Mikol, V., Didier, M., Escoubet, J.
Ligand|Inhibitor: 64D Ligand in structure: Ligplot


Reference

    Title: Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents
    Griebel G, Pichat P, Beeske S, Leroy T, Redon N, Jacquet A, Francon D, Bert L, Even L and Escoubet J <21 more author(s)>
    Ref: Sci Rep, 5:7642, 2015 : PubMed

            

    Title: Structural basis for human monoglyceride lipase inhibition
    Bertrand T, Auge F, Houtmann J, Rak A, Vallee F, Mikol V, Berne PF, Michot N, Cheuret D and Mathieu M <1 more author(s)>
    Ref: Journal of Molecular Biology, 396:663, 2010 : PubMed

            



Representative scheme of Monoglyceridelipase_lysophospholip structure and an image from PDBsum server

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Databases

PDB-Sum4UUQ Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP4UUQ Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP4UUQ Structural Classification Of Protein - SCOP server
PROTEOPEDIA4uuq 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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