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Structure Report for: 4W63

Name|Torpedo californica Acetylcholinesterase in complex with a tacrine-benzofuran hybrid inhibitor
Revelation date|09-Sep-2015
Family|ACHE: there are 538 genes in this family, 315 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Pesaresi, A., Samez, S., Lamba, D.
Ligand|Inhibitor: Tacrine-Benzofuran Ligand in structure: Ligplot


    Title: Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography
    Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, De Simone A and Bartolini M <6 more author(s)>
    Ref: Journal of Medicinal Chemistry, 59:114, 2016 : PubMed


Representative scheme of ACHE structure and an image from PDBsum server


PDB-Sum4W63 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP4W63 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP4W63 Structural Classification Of Protein - SCOP server
PROTEOPEDIA4w63 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

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