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Structure Report for: 5I7U

Name|Human DPP4 in complex with a novel tricyclic hetero-cycle inhibitor
Revelation date|08-Jun-2016
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
Gene_locus|human-DPP4
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Scapin, G
Ligand|Inhibitor: CHEMBL3687984 Ligand in structure: Ligplot


Reference

    Title: Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes
    Wu WL, Hao J, Domalski M, Burnett DA, Pissarnitski D, Zhao Z, Stamford A, Scapin G, Gao YD and Hwa J <6 more author(s)>
    Ref: ACS Med Chem Lett, 7:498, 2016 : PubMed

            



Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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Databases

PDB-Sum5I7U Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5I7U Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5I7U Structural Classification Of Protein - SCOP server
PROTEOPEDIA5i7u 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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