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Structure Report for: 5J3J

Name|Crystal Structure of human DPP-IV in complex with HL1
Revelation date|05-Apr-2017
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 182 structure(s)
Gene_locus|human-DPP4
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Wu, F., Li, H., Zhao, Z., Zhu, L., Xu, H., Li, S.
Ligand|Inhibitor: SCHEMBL19305555 Ligand in structure: Ligplot


Reference

    Title: Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes
    Li S, Qin C, Cui S, Xu H, Wu F, Wang J, Su M, Fang X, Li D and Li H <8 more author(s)>
    Ref: Journal of Medicinal Chemistry, 62:2348, 2019 : PubMed

            

    Title: Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes
    Li S, Xu H, Cui S, Wu F, Zhang Y, Su M, Gong Y, Qiu S, Jiao Q and Li H <13 more author(s)>
    Ref: Journal of Medicinal Chemistry, 59:6772, 2016 : PubMed

            



Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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Databases

PDB-Sum5J3J Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5J3J Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5J3J Structural Classification Of Protein - SCOP server
PROTEOPEDIA5j3j 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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