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Structure Report for: 5SYM

Name|Cocrystal structure of the human acyl protein thioesterase 1 with an isoform-selective inhibitor, ML348
Revelation date|26-Oct-2016
Family|LYsophospholipase_carboxylesterase: there are 343 genes in this family, 27 structure(s)
Gene_locus|human-LYPLA1
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Labby, K.J., Stuckey, J.A., Meagher, J.L., Won, S.J., Martin, B.R.
Ligand|Inhibitor: ML348 Ligand in structure: Ligplot


Reference

    Title: Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2)
    Won SJ, Davda D, Labby KJ, Hwang SY, Pricer R, Majmudar JD, Armacost KA, Rodriguez LA, Rodriguez CL and Martin BR <7 more author(s)>
    Ref: ACS Chemical Biology, 11:3374, 2016 : PubMed

            



Representative scheme of LYsophospholipase_carboxylesterase structure and an image from PDBsum server



Databases

PDB-Sum5SYM Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5SYM Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5SYM Structural Classification Of Protein - SCOP server
PROTEOPEDIA5sym 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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