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Structure Report for: 6AVY

Name|Crystal structure of Zea mays (Maize) acylprotein thioesterase ZmB6T1C9/ZmAPT2
Revelation date|27-Dec-2017
Family|LYsophospholipase_carboxylesterase: there are 336 genes in this family, 27 structure(s)
Gene_locus|maize-b6t1C9
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Burger et al. show that Acyl-protein thioesterase structures present a long tunnel for accommodation of long-chain fatty acids and release the product by use of a flexible loop tunnel lid. Homologous deacetylases use a hydrophobic residue to fix the lid and another residue to close the tunnel entrance. This causes loop rigidity changing the catalytic preference to deacetylation. ZmB6T1C9 as its paralogue in Arabidopsis At5G20060 is an acylprotein thioesterase and not an protein deacetylase
Ligand|


Reference

    Title: A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors
    Burger M, Willige BC, Chory J
    Ref: Nat Commun, 8:2201, 2017 : PubMed

            



Representative scheme of LYsophospholipase_carboxylesterase structure and an image from PDBsum server



Databases

PDB-Sum6AVY Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6AVY Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6AVY Structural Classification Of Protein - SCOP server
PROTEOPEDIA6avy 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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