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Structure Report for: 6B1O

Name|The structure of DPP4 in complex with Vildagliptin Analog
Revelation date|27-Sep-2017
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
Gene_locus|human-DPP4
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Berger, J.P., SinhaRoy, R., Pocai, A., Kelly, T.M., Scapin, G., Gao, Y.-D., Pryor, K.A.D., Wu, J., Eiermann, G.J., Xu, S., Zhang, X., Tatosian, D.A., Weber, A.E., Thornberry, N.A., Carr, R.D.
Ligand|Inhibitor: VildaSaxagliptin-analogue Ligand in structure: Ligplot


Reference

    Title: A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice
    Berger JP, SinhaRoy R, Pocai A, Kelly TM, Scapin G, Gao YD, Pryor KAD, Wu JK, Eiermann GJ and Carr RD <5 more author(s)>
    Ref: Endocrinol Diabetes Metab, 1:e00002, 2018 : PubMed

            



Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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Databases

PDB-Sum6B1O Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6B1O Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6B1O Structural Classification Of Protein - SCOP server
PROTEOPEDIA6b1o 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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