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Structure Report for: 6FR2

Name|Soluble epoxide hydrolase in complex with LK864 polar spirocyclic orally bioavailable urea inhibitor
Revelation date|12-Sep-2018
Family|Epoxide_hydrolase: there are 1154 genes in this family, 155 structure(s)
Gene_locus|human-EPHX2
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Kramer, J.S., Pogoryelov, D., Krasavin, M., Proschak, E.
Ligand|Inhibitor: LK864 Ligand in structure: Ligplot


Reference

    Title: Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase
    Lukin A, Kramer J, Hartmann M, Weizel L, Hernandez-Olmos V, Falahati K, Burghardt I, Kalinchenkova N, Bagnyukova D and Krasavin M <10 more author(s)>
    Ref: Bioorg Chem, 80:655, 2018 : PubMed

            



Representative scheme of Epoxide_hydrolase structure and an image from PDBsum server

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Databases

PDB-Sum6FR2 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6FR2 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6FR2 Structural Classification Of Protein - SCOP server
PROTEOPEDIA6fr2 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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