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Structure Report for: 6G4N

Name|Torpedo californica acetylcholinesterase bound to uncharged hybrid reactivator Tacrine-pyridinealdoxime-2
Revelation date|29-Aug-2018
Family|ACHE: there are 538 genes in this family, 315 structure(s)
Gene_locus|torca-ACHE
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Santoni, G., De la Mora, E., de Souza, J., Silman, I., Sussman, J., Baati, R., Weik, M., Nachon, F.
Ligand|Reactivator: Tacrine-pyridinealdoxime-2 Ligand in structure: Ligplot


Reference

    Title: Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
    Santoni G, de Sousa J, De la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD and Nachon F <2 more author(s)>
    Ref: Journal of Medicinal Chemistry, 61:7630, 2018 : PubMed

            



Representative scheme of ACHE structure and an image from PDBsum server



Databases

PDB-Sum6G4N Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6G4N Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6G4N Structural Classification Of Protein - SCOP server
PROTEOPEDIA6g4n 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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