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Structure Report for: 6H14

Name|Crystal structure of Torpedo californica ACHE complexed to 1-(6-oxo-1,2,3,4,6,10b-hexahydropyrido[2,1-a]isoindol-10-yl)-3-(4-(1-(2-((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)-1H-1,2,3-triazol-4-yl)pyridin-2-yl)urea
Revelation date|15-May-2019
Family|ACHE: there are 538 genes in this family, 315 structure(s)
Gene_locus|torca-ACHE
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Coquelle, N., Colletier, J.P.
Ligand|Inhibitor: 6H14-(S)6 Ligand in structure: Ligplot


Reference

    Title: Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3
    Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M and Renard PY <9 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 168:58, 2019 : PubMed

            



Representative scheme of ACHE structure and an image from PDBsum server



Databases

PDB-Sum6H14 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6H14 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6H14 Structural Classification Of Protein - SCOP server
PROTEOPEDIA6h14 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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