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Structure Report for: 6R8P

Name|Structure of the Wnt deacetylase notum with inhibitor fragment 723 JVB Pyridine
Revelation date|08-May-2019
Family|Pectinacetylesterase-Notum: there are 695 genes in this family, 143 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Atkinson, B.N., Steadman, D., Zhao, Y., Sipthorp, J., Vecchia, L., Ruza, R.R., Jegnathan, F., Lines, G., Frew, S., Monaghan, A., Kjaer, S., Bictash, M., Jones, Y., Fish, P.V.
Ligand|Inhibitor: JVB Ligand in structure: Ligplot


    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed


    Title: Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen
    Atkinson BN, Steadman D, Zhao YG, Sipthorp J, Vecchia L, Ruza RR, Jeganathan F, Lines G, Frew S and Jones EY <6 more author(s)>
    Ref: Medchemcomm, 10:1361, 2019 : PubMed


Representative scheme of Pectinacetylesterase-Notum structure and an image from PDBsum server

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PDB-Sum6R8P Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6R8P Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6R8P Structural Classification Of Protein - SCOP server
PROTEOPEDIA6r8p 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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