Structure

Tree Display

AceDB Schema

XML Display

Feedback

Structure Report for: 6R8P

Name|Structure of the Wnt deacetylase notum with inhibitor fragment 723 JVB Pyridine
Revelation date|08-May-2019
Family|Pectinacetylesterase-Notum: there are 695 genes in this family, 129 structure(s)
Gene_locus|human-NOTUM
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Atkinson, B.N., Steadman, D., Zhao, Y., Sipthorp, J., Vecchia, L., Ruza, R.R., Jegnathan, F., Lines, G., Frew, S., Monaghan, A., Kjaer, S., Bictash, M., Jones, Y., Fish, P.V.
Ligand|Inhibitor: JVB Ligand in structure: Ligplot


Reference

    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed

            

    Title: Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen
    Atkinson BN, Steadman D, Zhao YG, Sipthorp J, Vecchia L, Ruza RR, Jeganathan F, Lines G, Frew S and Jones EY <6 more author(s)>
    Ref: Medchemcomm, 10:1361, 2019 : PubMed

            



Representative scheme of Pectinacetylesterase-Notum structure and an image from PDBsum server

no Image


Databases

PDB-Sum6R8P Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6R8P Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6R8P Structural Classification Of Protein - SCOP server
PROTEOPEDIA6r8p 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer