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Structure Report for: 6S6E

Name|Crystal structure of the engineered ancestor of haloalkane dehalogenases and Renilla luciferase (AncHLD-RLuc I161_F162PinsL)
Revelation date|27-Jan-2021
Family|Haloalkane_dehalogenase-HLD2: there are 72 genes in this family, 110 structure(s)
Gene_locus|9zzzz-AncHLDRLuc
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Schenkmayerova, A., Damborsky, J., Marek, M. Luciferase from Renilla reniformis (RLuc) catalyzes the degradation of coelenterazine in the presence of molecular oxygen, resulting in the product coelenteramide, carbon dioxide, and the desired photon of light (EC 1.13.12.5). This enzyme belongs to the Haloalkane dehalogenase family II with a different catalytic function (EC 3.8.1.5) Reconstruction of an ancestral enzyme shows it has both hydrolase and monooxygenase activities ( Chaloupkova et al.) Preprint available of: Engineering Protein Dynamics of Ancestral Luciferase DOI: 10.26434/chemrxiv.12808295
Ligand|


Reference

    Title: Engineering the protein dynamics of an ancestral luciferase
    Schenkmayerova A, Pinto GP, Toul M, Marek M, Hernychova L, Planas-Iglesias J, Daniel Liskova V, Pluskal D, Vasina M and Damborsky J <7 more author(s)>
    Ref: Nat Commun, 12:3616, 2021 : PubMed

            

    Title: Engineering Protein Dynamics of Ancestral Luciferase
    Schenkmayerova A, Pinto GP, Toul M, Marek M, Hernychova L, Planas-Iglesias J, Liskova V, Pluskal D, Vasina M and Damborsky J <7 more author(s)>
    Ref: Chemrxiv, :, 2020 : PubMed

            



Representative scheme of Haloalkane_dehalogenase-HLD2 structure and an image from PDBsum server



Databases

PDB-Sum6S6E Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6S6E Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6S6E Structural Classification Of Protein - SCOP server
PROTEOPEDIA6s6e 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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