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Structure Report for: 6YL4

Name|Soluble epoxide hydrolase in complex with 3-((R)-3-(1-hydroxyureido)but-1-yn-1-yl)-N-((S)-3-phenyl-3-(4-trifluoromethoxy)phenyl)propyl)benzamide
Revelation date|21-Oct-2020
Family|Epoxide_hydrolase: there are 1154 genes in this family, 155 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Kramer, J.S., Pogoryelov, D., Hiesinger, K., Proschak, E
Ligand|Inhibitor: OWW-6YL4 Ligand in structure: Ligplot


    Title: Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase
    Hiesinger K, Kramer JS, Beyer S, Eckes T, Brunst S, Flauaus C, Wittmann SK, Weizel L, Kaiser A and Proschak E <12 more author(s)>
    Ref: Journal of Medicinal Chemistry, 63:11498, 2020 : PubMed


Representative scheme of Epoxide_hydrolase structure and an image from PDBsum server

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PDB-Sum6YL4 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6YL4 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6YL4 Structural Classification Of Protein - SCOP server
PROTEOPEDIA6yl4 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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