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Structure Report for: 6YN2

Name|Crystal structure of Renilla reniformis luciferase variant RLuc8-W121F/E144Q in complex with a coelenteramide (the postcatalytic enzyme-product complex)
Revelation date|21-Apr-2021
Family|Haloalkane_dehalogenase-HLD2: there are 72 genes in this family, 110 structure(s)
Gene_locus|renre-luc
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Schenkmayerova, A., Damborsky, J., Marek, M. Luciferase from Renilla reniformis (RLuc) catalyzes the degradation of coelenterazine in the presence of molecular oxygen, resulting in the product coelenteramide, carbon dioxide, and the desired photon of light (EC 1.13.12.5). This enzyme belongs to the Haloalkane dehalogenase family II with a different catalytic function (EC 3.8.1.5) Reconstruction of an ancestral enzyme shows it has both hydrolase and monooxygenase activities ( Chaloupkova et al.) Preprint available of: Engineering Protein Dynamics of Ancestral Luciferase DOI: 10.26434/chemrxiv.12808295
Ligand|Inhibitor: Coelenteramide Ligand in structure: Ligplot


Reference

    Title: Engineering the protein dynamics of an ancestral luciferase
    Schenkmayerova A, Pinto GP, Toul M, Marek M, Hernychova L, Planas-Iglesias J, Daniel Liskova V, Pluskal D, Vasina M and Damborsky J <7 more author(s)>
    Ref: Nat Commun, 12:3616, 2021 : PubMed

            

    Title: Engineering Protein Dynamics of Ancestral Luciferase
    Schenkmayerova A, Pinto GP, Toul M, Marek M, Hernychova L, Planas-Iglesias J, Liskova V, Pluskal D, Vasina M and Damborsky J <7 more author(s)>
    Ref: Chemrxiv, :, 2020 : PubMed

            



Representative scheme of Haloalkane_dehalogenase-HLD2 structure and an image from PDBsum server



Databases

PDB-Sum6YN2 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6YN2 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6YN2 Structural Classification Of Protein - SCOP server
PROTEOPEDIA6yn2 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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