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Structure Report for: 6YSK

Name|1-phenylpyrroles and 1-enylpyrrolidines as inhibitors of Notum
Revelation date|16-Sep-2020
Family|Pectinacetylesterase-Notum: there are 695 genes in this family, 129 structure(s)
Gene_locus|human-NOTUM
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Zhao, Y., Jones, E.Y., Fish, P.
Ligand|Inhibitor: Pyrrole-26-6YSK Ligand in structure: Ligplot


Reference

    Title: Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
    Mahy W, Patel M, Steadman D, Woodward HL, Atkinson BN, Svensson F, Willis NJ, Flint A, Papatheodorou D and Fish PV <10 more author(s)>
    Ref: Journal of Medicinal Chemistry, 63:9464, 2020 : PubMed

            



Representative scheme of Pectinacetylesterase-Notum structure and an image from PDBsum server

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Databases

PDB-Sum6YSK Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6YSK Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6YSK Structural Classification Of Protein - SCOP server
PROTEOPEDIA6ysk 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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