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Structure Report for: 6ZUV

Name|Structure of the Wnt deacylase Notum in complex with fragment 286 (Compound 7, 4F-329S)
Revelation date|11-Nov-2020
Family|Pectinacetylesterase-Notum: there are 695 genes in this family, 129 structure(s)
Gene_locus|human-NOTUM
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Zhao, Y.,Jones, E.Y.
Ligand|Inhibitor: 4F-329S Ligand in structure: Ligplot


Reference

    Title: Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit
    Willis NJ, Mahy W, Sipthorp J, Zhao Y, Woodward HL, Atkinson BN, Bayle ED, Svensson F, Frew S and Fish PV <14 more author(s)>
    Ref: Journal of Medicinal Chemistry, :, 2022 : PubMed

            

    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed

            

    Title: 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit
    Mahy W, Willis NJ, Zhao Y, Woodward HL, Svensson F, Sipthorp J, Vecchia L, Ruza RR, Hillier J and Fish PV <8 more author(s)>
    Ref: Journal of Medicinal Chemistry, 63:12942, 2020 : PubMed

            



Representative scheme of Pectinacetylesterase-Notum structure and an image from PDBsum server

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Databases

PDB-Sum6ZUV Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6ZUV Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6ZUV Structural Classification Of Protein - SCOP server
PROTEOPEDIA6zuv 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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