Tree Display

AceDB Schema

XML Display


Structure Report for: 6ZVL

Name|Structure of the Wnt deacylase Notum in complex with SCHEMBL21776992 (ARUK3000263 Compound23dd 7a)
Revelation date|11-Nov-2020
Family|Pectinacetylesterase-Notum: there are 695 genes in this family, 129 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Zhao, Y.,Jones, E.Y.
Ligand|Inhibitor: SCHEMBL21776992 Ligand in structure: Ligplot


    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed


    Title: 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit
    Mahy W, Willis NJ, Zhao Y, Woodward HL, Svensson F, Sipthorp J, Vecchia L, Ruza RR, Hillier J and Fish PV <8 more author(s)>
    Ref: Journal of Medicinal Chemistry, 63:12942, 2020 : PubMed


Representative scheme of Pectinacetylesterase-Notum structure and an image from PDBsum server

no Image


PDB-Sum6ZVL Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6ZVL Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6ZVL Structural Classification Of Protein - SCOP server
PROTEOPEDIA6zvl 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

Acknowledgements and disclaimer