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Structure Report for: 7QAK

Name|Mus musculus Acetylcholinesterase in complex with 7-[(4-{[benzyl(methyl)amino]methyl}benzyl)oxy]-4-(hydroxymethyl)-2H-chromen-2-one multitargeting inhibitor of AChE and MAO
Revelation date|06-Apr-2022
Family|ACHE: there are 538 genes in this family, 315 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Fredrik Ekstrom, Andrea Gottinger, Nina Forsgren, Marco Catto, Luca G. Iacovino, Leonardo Pisani, and Claudia Binda
Ligand|Inhibitor: 7QAK-Cpd1 Ligand in structure: Ligplot


    Title: Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures
    Ekstrom F, Gottinger A, Forsgren N, Catto M, Iacovino LG, Pisani P, Binda C
    Ref: ACS Med Chem Lett, 13:499, 2022 : PubMed


Representative scheme of ACHE structure and an image from PDBsum server


PDB-Sum7QAK Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP7QAK Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP7QAK Structural Classification Of Protein - SCOP server
PROTEOPEDIA7qak 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

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