Epigallocatechin-gallate
General
Type : Derivative of Gallate || Benzoate || Natural || Polyphenol
Chemical_Nomenclature : [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Canonical SMILES : C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
InChI : InChI=1S\/C22H18O11\/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8\/h1-6,18,21,23-30H,7H2\/t18-,21-\/m1\/s1
InChIKey : WMBWREPUVVBILR-WIYYLYMNSA-N
Other name(s) : EGCG, Epigallocatechin gallate, Epigallocatechin 3-gallate, Epigallocatechin-3-gallate, epigallocatechin-3-O-gallate, (-)-Epigallocatechin gallate, CHEBI:4806, CHEMBL297453, Gallic acid, 3-ester with epigallocatechol, (-)-
Target
Families : AlphaBeta_hydrolase, Plant_carboxylesterase
References (26)
| Title : New insights into the function of plant tannase with promiscuous acyltransferase activity - Chen_2022_Plant.J__ |
| Author(s) : Chen Y , Jiang C , Yin S , Zhuang J , Zhao Y , Zhang L , Jiang X , Liu Y , Gao L , Xia T |
| Ref : Plant J , : , 2022 |
| Abstract : Chen_2022_Plant.J__ |
| ESTHER : Chen_2022_Plant.J__ |
| PubMedSearch : Chen_2022_Plant.J__ |
| PubMedID: 36534122 |
| Gene_locus related to this paper: camsi-CsTA |
| Title : Degradation of epigallocatechin and epicatechin gallates by a novel tannase Tan(Hcw) from Herbaspirillum camelliae - Lei_2021_Microb.Cell.Fact_20_197 |
| Author(s) : Lei J , Zhang Y , Ni X , Yu X , Wang X |
| Ref : Microb Cell Fact , 20 :197 , 2021 |
| Abstract : Lei_2021_Microb.Cell.Fact_20_197 |
| ESTHER : Lei_2021_Microb.Cell.Fact_20_197 |
| PubMedSearch : Lei_2021_Microb.Cell.Fact_20_197 |
| PubMedID: 34641872 |
| Gene_locus related to this paper: 9burk-TanHcw |
| Title : Genome-Wide Identification of Tannase Genes and Their Function of Wound Response and Astringent Substances Accumulation in Juglandaceae - Wang_2021_Front.Plant.Sci_12_664470 |
| Author(s) : Wang J , Wang K , Lyu S , Huang J , Huang C , Xing Y , Wang Y , Xu Y , Li P , Hong J , Xi J , Si X , Ye H , Li Y |
| Ref : Front Plant Sci , 12 :664470 , 2021 |
| Abstract : Wang_2021_Front.Plant.Sci_12_664470 |
| ESTHER : Wang_2021_Front.Plant.Sci_12_664470 |
| PubMedSearch : Wang_2021_Front.Plant.Sci_12_664470 |
| PubMedID: 34079571 |
| Gene_locus related to this paper: camsi-CsTA |
| Title : Structural characterization and antioxidant property of enzymatic-transesterification derivatives of (-)-epigallocatechin-3-O-gallate and vinyl laurate - Jiang_2021_J.Food.Sci__ |
| Author(s) : Jiang C , Wang L , Huang X , Zhu S , Ma C , Wang H |
| Ref : J Food Sci , : , 2021 |
| Abstract : Jiang_2021_J.Food.Sci__ |
| ESTHER : Jiang_2021_J.Food.Sci__ |
| PubMedSearch : Jiang_2021_J.Food.Sci__ |
| PubMedID: 34553787 |
| Title : Epigallocatechin-3-gallate improves chronic alcohol-induced cognitive dysfunction in rats by interfering with neuro-inflammatory, cell death and oxido-nitrosative cascade - Uniyal_2021_Metab.Brain.Dis__ |
| Author(s) : Uniyal A , Akhilesh , Tiwari V , Gadepalli A , Ummadisetty O |
| Ref : Metabolic Brain Disease , : , 2021 |
| Abstract : Uniyal_2021_Metab.Brain.Dis__ |
| ESTHER : Uniyal_2021_Metab.Brain.Dis__ |
| PubMedSearch : Uniyal_2021_Metab.Brain.Dis__ |
| PubMedID: 34386880 |
| Title : Epigallocatechin-3-Gallate Provides Protection Against Alzheimer's Disease-Induced Learning and Memory Impairments in Rats - Nan_2021_Drug.Des.Devel.Ther_15_2013 |
| Author(s) : Nan S , Wang P , Zhang Y , Fan J |
| Ref : Drug Des Devel Ther , 15 :2013 , 2021 |
| Abstract : Nan_2021_Drug.Des.Devel.Ther_15_2013 |
| ESTHER : Nan_2021_Drug.Des.Devel.Ther_15_2013 |
| PubMedSearch : Nan_2021_Drug.Des.Devel.Ther_15_2013 |
| PubMedID: 34012254 |
| Title : Therapeutic effects of biochanin A, phloretin, and epigallocatechin-3-gallate in reducing oxidative stress in arsenic-intoxicated mice - Singh_2021_Environ.Sci.Pollut.Res.Int__ |
| Author(s) : Singh G , Thaker R , Sharma A , Parmar D |
| Ref : Environ Sci Pollut Res Int , : , 2021 |
| Abstract : Singh_2021_Environ.Sci.Pollut.Res.Int__ |
| ESTHER : Singh_2021_Environ.Sci.Pollut.Res.Int__ |
| PubMedSearch : Singh_2021_Environ.Sci.Pollut.Res.Int__ |
| PubMedID: 33410021 |
| Title : Role of human AADAC on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity - Hirosawa_2021_Drug.Metab.Dispos__ |
| Author(s) : Hirosawa K , Fukami T , Tashiro K , Sakai Y , Kisui F , Nakano M , Nakajima M |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021 |
| Abstract : Hirosawa_2021_Drug.Metab.Dispos__ |
| ESTHER : Hirosawa_2021_Drug.Metab.Dispos__ |
| PubMedSearch : Hirosawa_2021_Drug.Metab.Dispos__ |
| PubMedID: 33446525 |
| Gene_locus related to this paper: human-AADAC |
| Title : Discovery and characterization of tannase genes in plants: roles in hydrolysis of tannins - Dai_2020_New.Phytol_226_1104 |
| Author(s) : Dai X , Liu Y , Zhuang J , Yao S , Liu L , Jiang X , Zhou K , Wang Y , Xie D , Bennetzen JL , Gao L , Xia T |
| Ref : New Phytol , 226 :1104 , 2020 |
| Abstract : Dai_2020_New.Phytol_226_1104 |
| ESTHER : Dai_2020_New.Phytol_226_1104 |
| PubMedSearch : Dai_2020_New.Phytol_226_1104 |
| PubMedID: 32061142 |
| Gene_locus related to this paper: camsi-a0a5b9g8c2 , jugre-JrTA , fraan-FaTA , vitvi-VvTA , citcl-CcTA , dioka-DkTA , camsi-CsTA |
| Title : Protective Role of Epigallocatechin Gallate in a Rat Model of Cisplatin-Induced Cerebral Inflammation and Oxidative Damage: Impact of Modulating NF-kappaB and Nrf2 - Arafa_2020_Neurotox.Res_37_380 |
| Author(s) : Arafa MH , Atteia HH |
| Ref : Neurotox Res , 37 :380 , 2020 |
| Abstract : Arafa_2020_Neurotox.Res_37_380 |
| ESTHER : Arafa_2020_Neurotox.Res_37_380 |
| PubMedSearch : Arafa_2020_Neurotox.Res_37_380 |
| PubMedID: 31410684 |
| Title : Dipeptidyl Peptidase-4 Is a Target Protein of Epigallocatechin-3-Gallate - Hou_2020_Biomed.Res.Int_2020_5370759 |
| Author(s) : Hou H , Wang Y , Li C , Wang J , Cao Y |
| Ref : Biomed Res Int , 2020 :5370759 , 2020 |
| Abstract : Hou_2020_Biomed.Res.Int_2020_5370759 |
| ESTHER : Hou_2020_Biomed.Res.Int_2020_5370759 |
| PubMedSearch : Hou_2020_Biomed.Res.Int_2020_5370759 |
| PubMedID: 32104696 |
| Title : Novel Hybrid Molecules Based on (-)-Epigallocatechin Gallate as Potent Anti-adipogenic Agents - Jeong_2020_Chem.Pharm.Bull.(Tokyo)_68_1155 |
| Author(s) : Jeong GH , Cho JH , Jo C , Park S , Kim SB , Kim TH |
| Ref : Chem Pharm Bull (Tokyo) , 68 :1155 , 2020 |
| Abstract : Jeong_2020_Chem.Pharm.Bull.(Tokyo)_68_1155 |
| ESTHER : Jeong_2020_Chem.Pharm.Bull.(Tokyo)_68_1155 |
| PubMedSearch : Jeong_2020_Chem.Pharm.Bull.(Tokyo)_68_1155 |
| PubMedID: 33268647 |
| Title : Membrane order and ionic strength modulation of the inhibition of the membrane-bound acetylcholinesterase by epigallocatechin3gallate - Salazar_2019_Biochim.Biophys.Acta.Biomembr_1861_170 |
| Author(s) : Salazar PB , Dupuy FG , de Athayde Moncorvo Collado A , Minahk CJ |
| Ref : Biochimica & Biophysica Acta Biomembr , 1861 :170 , 2019 |
| Abstract : Salazar_2019_Biochim.Biophys.Acta.Biomembr_1861_170 |
| ESTHER : Salazar_2019_Biochim.Biophys.Acta.Biomembr_1861_170 |
| PubMedSearch : Salazar_2019_Biochim.Biophys.Acta.Biomembr_1861_170 |
| PubMedID: 30463700 |
| Title : (-)Epigallocatechin-3-gallate attenuates anesthesiainduced memory deficit in young mice via modulation of nitric oxide expression - Ding_2018_Mol.Med.Rep_18_4813 |
| Author(s) : Ding L , Gao X , Hu J , Yu S |
| Ref : Mol Med Rep , 18 :4813 , 2018 |
| Abstract : Ding_2018_Mol.Med.Rep_18_4813 |
| ESTHER : Ding_2018_Mol.Med.Rep_18_4813 |
| PubMedSearch : Ding_2018_Mol.Med.Rep_18_4813 |
| PubMedID: 30320383 |
| Title : Differential inhibition of human erythrocyte acetylcholinesterase by polyphenols epigallocatechin-3-gallate and resveratrol. Relevance of the membrane-bound form - Salazar_2017_Biofactors_43_73 |
| Author(s) : Salazar PB , de Athayde Moncorvo Collado A , Canal-Martinez V , Minahk CJ |
| Ref : Biofactors , 43 :73 , 2017 |
| Abstract : Salazar_2017_Biofactors_43_73 |
| ESTHER : Salazar_2017_Biofactors_43_73 |
| PubMedSearch : Salazar_2017_Biofactors_43_73 |
| PubMedID: 27591048 |
| Title : Epigallocatechin-3-gallate attenuates cerebral cortex damage and promotes brain regeneration in acrylamide-treated rats - He_2017_Food.Funct_8_2275 |
| Author(s) : He Y , Tan D , Mi Y , Zhou Q , Ji S |
| Ref : Food Funct , 8 :2275 , 2017 |
| Abstract : He_2017_Food.Funct_8_2275 |
| ESTHER : He_2017_Food.Funct_8_2275 |
| PubMedSearch : He_2017_Food.Funct_8_2275 |
| PubMedID: 28561817 |
| Title : Effect of epigallocatechin-3-gallate on acrylamide-induced oxidative stress and apoptosis in PC12 cells - He_2017_Hum.Exp.Toxicol_36_1087 |
| Author(s) : He Y , Tan D , Mi Y , Bai B , Jiang D , Zhou X , Ji S |
| Ref : Hum Exp Toxicol , 36 :1087 , 2017 |
| Abstract : He_2017_Hum.Exp.Toxicol_36_1087 |
| ESTHER : He_2017_Hum.Exp.Toxicol_36_1087 |
| PubMedSearch : He_2017_Hum.Exp.Toxicol_36_1087 |
| PubMedID: 27920337 |
| Title : A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines - Machova_2017_Neuropharmacol_126_213 |
| Author(s) : Machova Urdzikova L , Ruzicka J , Karova K , Kloudova A , Svobodova B , Amin A , Dubisova J , Schmidt M , Kubinova S , Jhanwar-Uniyal M , Jendelova P |
| Ref : Neuropharmacology , 126 :213 , 2017 |
| Abstract : Machova_2017_Neuropharmacol_126_213 |
| ESTHER : Machova_2017_Neuropharmacol_126_213 |
| PubMedSearch : Machova_2017_Neuropharmacol_126_213 |
| PubMedID: 28899730 |
| Title : Fast identification of lipase inhibitors in oolong tea by using lipase functionalised Fe3O4 magnetic nanoparticles coupled with UPLC-MS\/MS - Zhu_2015_Food.Chem_173_521 |
| Author(s) : Zhu YT , Ren XY , Yuan L , Liu YM , Liang J , Liao X |
| Ref : Food Chem , 173 :521 , 2015 |
| Abstract : Zhu_2015_Food.Chem_173_521 |
| ESTHER : Zhu_2015_Food.Chem_173_521 |
| PubMedSearch : Zhu_2015_Food.Chem_173_521 |
| PubMedID: 25466054 |
| Title : Molecular Interactions between (-)-Epigallocatechin Gallate Analogs and Pancreatic Lipase - Wang_2014_PLoS.One_9_e111143 |
| Author(s) : Wang S , Sun Z , Dong S , Liu Y |
| Ref : PLoS ONE , 9 :e111143 , 2014 |
| Abstract : Wang_2014_PLoS.One_9_e111143 |
| ESTHER : Wang_2014_PLoS.One_9_e111143 |
| PubMedSearch : Wang_2014_PLoS.One_9_e111143 |
| PubMedID: 25365042 |
| Title : Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia - Biasibetti_2013_Behav.Brain.Res_236_186 |
| Author(s) : Biasibetti R , Tramontina AC , Costa AP , Dutra MF , Quincozes-Santos A , Nardin P , Bernardi CL , Wartchow KM , Lunardi PS , Goncalves CA |
| Ref : Behavioural Brain Research , 236 :186 , 2013 |
| Abstract : Biasibetti_2013_Behav.Brain.Res_236_186 |
| ESTHER : Biasibetti_2013_Behav.Brain.Res_236_186 |
| PubMedSearch : Biasibetti_2013_Behav.Brain.Res_236_186 |
| PubMedID: 22964138 |
| Title : (-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice - Grove_2012_Obesity.(Silver.Spring)_20_2311 |
| Author(s) : Grove KA , Sae-tan S , Kennett MJ , Lambert JD |
| Ref : Obesity (Silver Spring) , 20 :2311 , 2012 |
| Abstract : Grove_2012_Obesity.(Silver.Spring)_20_2311 |
| ESTHER : Grove_2012_Obesity.(Silver.Spring)_20_2311 |
| PubMedSearch : Grove_2012_Obesity.(Silver.Spring)_20_2311 |
| PubMedID: 21633405 |
| Gene_locus related to this paper: human-PNLIP |
| Title : Impact of epigallo catechin-3-gallate on acetylcholine-acetylcholine esterase cycle in aged rat brain - Srividhya_2012_Neurochem.Int_60_517 |
| Author(s) : Srividhya R , Gayathri R , Kalaiselvi P |
| Ref : Neurochem Int , 60 :517 , 2012 |
| Abstract : Srividhya_2012_Neurochem.Int_60_517 |
| ESTHER : Srividhya_2012_Neurochem.Int_60_517 |
| PubMedSearch : Srividhya_2012_Neurochem.Int_60_517 |
| PubMedID: 22366543 |
| Title : Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced alpha9-nicotinic acetylcholine receptor upregulation in human breast cancer cells - Tu_2011_Mol.Nutr.Food.Res_55_455 |
| Author(s) : Tu SH , Ku CY , Ho CT , Chen CS , Huang CS , Lee CH , Chen LC , Pan MH , Chang HW , Chang CH , Chang YJ , Wei PL , Wu CH , Ho YS |
| Ref : Mol Nutr Food Res , 55 :455 , 2011 |
| Abstract : Tu_2011_Mol.Nutr.Food.Res_55_455 |
| ESTHER : Tu_2011_Mol.Nutr.Food.Res_55_455 |
| PubMedSearch : Tu_2011_Mol.Nutr.Food.Res_55_455 |
| PubMedID: 21370452 |
| Title : Epigallocatechin-3-gallate ameliorates alcohol-induced cognitive dysfunctions and apoptotic neurodegeneration in the developing rat brain - Tiwari_2010_Int.J.Neuropsychopharmacol_13_1053 |
| Author(s) : Tiwari V , Kuhad A , Chopra K |
| Ref : Int J Neuropsychopharmacol , 13 :1053 , 2010 |
| Abstract : Tiwari_2010_Int.J.Neuropsychopharmacol_13_1053 |
| ESTHER : Tiwari_2010_Int.J.Neuropsychopharmacol_13_1053 |
| PubMedSearch : Tiwari_2010_Int.J.Neuropsychopharmacol_13_1053 |
| PubMedID: 20529413 |
| Title : Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length - Mori_2008_Bioorg.Med.Chem.Lett_18_4249 |
| Author(s) : Mori S , Miyake S , Kobe T , Nakaya T , Fuller SD , Kato N , Kaihatsu K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4249 , 2008 |
| Abstract : Mori_2008_Bioorg.Med.Chem.Lett_18_4249 |
| ESTHER : Mori_2008_Bioorg.Med.Chem.Lett_18_4249 |
| PubMedSearch : Mori_2008_Bioorg.Med.Chem.Lett_18_4249 |
| PubMedID: 18547804 |