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Substrate Report for: 14,15-EET

General
Type Epoxide
Chemical_Nomenclature 13-(3-pentyloxiran-2-yl)trideca-5,8,11-trienoic acid
Canonical SMILES CCCCCC1C(O1)CC=CCC=CCC=CCCCC(=O)O
InChI InChI=1S/C20H32O3/c1-2-3-12-15-18-19(23-18)16-13-10-8-6-4-5-7-9-11-14-17-20(21)22/h4,6-7,9-10,13,18-19H,2-3,5,8,11-12,14-17H2,1H3,(H,21,22)
InChIKey JBSCUHKPLGKXKH-UHFFFAOYSA-N
Other name(s) 13-(3-pentyloxiran-2-yl)trideca-5,8,11-trienoic acid ; 14,15-Epoxy-5,8,11-eicosatrienoic acid ; 14(15)-EpETrE ; (+/-)14,15-EPOXYEICOSA-5Z,8Z,11Z-TRIENOIC ACID ; 105304-92-5
________________________________________________________________________________________________
MW|320.47
Formula|C20H32O3
CAS_number|81276-03-1
PubChem|1431
UniChem|JBSCUHKPLGKXKH-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | 14,15-EET ligand of proteins in family: Epoxide_hydrolase, CFTR-inhibitory-factor_Cif
Stucture | 1 structure: 5JYC: Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EET hydrolysis intermediate
Protein | human-EPHX2, human-EPHX3, pseae-PA2934

References:
Search PubMed for references concerning: 14,15-EET

6 more
    Title: Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition
    Fang X, Kaduce TL, Weintraub NL, Harmon S, Teesch LM, Morisseau C, Thompson DA, Hammock BD, Spector AA
    Ref: Journal of Biological Chemistry, 276:14867, 2001 : PubMed

            

    Title: Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids
    Yu Z, Xu F, Huse LM, Morisseau C, Draper AJ, Newman JW, Parker C, Graham L, Engler MM and Kroetz DL <2 more author(s)>
    Ref: Circulation Research, 87:992, 2000 : PubMed

            

    Title: Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids
    Weintraub NL, Fang X, Kaduce TL, VanRollins M, Chatterjee P, Spector AA
    Ref: American Journal of Physiology, 277:H2098, 1999 : PubMed