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Substrate Report for: Aclacinomycin

General
Type Antibiotic
Chemical_Nomenclature methyl (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(dimethylamino)-5-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate
Canonical SMILES CCC1(CC(C2=C(C1C(=O)OC)C=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4O)OC5CC(C(C(O5)C)O)N(C)C)O
InChI InChI=1S/C30H35NO10/c1-6-30(38)12-19(41-20-11-17(31(3)4)25(33)13(2)40-20)22-15(24(30)29(37)39-5)10-16-23(28(22)36)27(35)21-14(26(16)34)8-7-9-18(21)32/h7-10,13,17,19-20,24-25,32-33,36,38H,6,11-12H2,1-5H3/t13-,17-,19-,20-,24-,25+,30+/m0/s1
InChIKey LJZPVWKMAYDYAS-QKKPTTNWSA-N
Other name(s) Aklavin ; Aclacinomycin T ; Doxypyrromycin ; 1-Deoxypyrromycin ; Rhodosaminyl-aklavinone
________________________________________________________________________________________________
MW|569.59
Formula|C30H35NO10
CAS_number|60504-57-6
PubChem|149755
UniChem|LJZPVWKMAYDYAS-QKKPTTNWSA-N
IUPHAR|
Wikipedia|

Target
Families | Aclacinomycin ligand of proteins in family: Aclacinomycin-methylesterase_RdmC
Stucture | 2 structures: 1Q0R, 1Q0Z
Protein | strpu-rdmC

References:
Search PubMed for references concerning: Aclacinomycin
    Title: Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism
    Jansson A, Niemi J, Mantsala P, Schneider G
    Ref: Journal of Biological Chemistry, 278:39006, 2003 : PubMed

            

    Title: Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens
    Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P
    Ref: Biochimica & Biophysica Acta, 1480:191, 2000 : PubMed