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Substrate Report for: CMNGC

Fluorescent substrate for microsomal epoxide hydrolase


General
Type Fluorescent Probe, Epoxide, Cyanide, Naphthalen
Chemical_Nomenclature [cyano-(6-methoxynaphthalen-2-yl)methyl] oxiran-2-ylmethyl carbonate
Canonical SMILES COC1=CC2=C(C=C1)C=C(C=C2)C(C#N)OC(=O)OCC3CO3
InChI InChI=1S/C17H15NO5/c1-20-14-5-4-11-6-13(3-2-12(11)7-14)16(8-18)23-17(19)22-10-15-9-21-15/h2-7,15-16H,9-10H2,1H3
InChIKey DWESTMUBUFIKPF-UHFFFAOYSA-N
Other name(s) Carbonic acid glycidyl[cyano(6-methoxy-2-naphthyl)methyl] ester
________________________________________________________________________________________________
MW|313.30
Formula|C17H15NO5
CAS_number|
PubChem|101796102
UniChem|DWESTMUBUFIKPF-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | CMNGC ligand of proteins in family: Epoxide_hydrolase, CFTR-inhibitory-factor_Cif

References:
Search PubMed for references concerning: CMNGC

1 more
    Title: Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei
    de Oliveira GS, Adriani PP, Wu H, Morisseau C, Hammock BD, Chambergo FS
    Ref: Mol Biol Rep, 46:371, 2019 : PubMed

            

    Title: Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif
    Bahl CD, Hvorecny KL, Morisseau C, Gerber SA, Madden DR
    Ref: Biochemistry, 55:788, 2016 : PubMed

            

    Title: Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies
    Morisseau C, Bernay M, Escaich A, Sanborn JR, Lango J, Hammock BD
    Ref: Analytical Biochemistry, 414:154, 2011 : PubMed