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Substrate Report for: Cholesterol

Cholesterol is the principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Cholesterol is an important component of the membranes of cells, providing stability. It is the major precursor for the synthesis of vitamin D, of the various steroid hormones, including cortisol, cortisone, and aldosterone in the adrenal glands, and of the sex hormones progesterone, estrogen, and testosterone. Cholesterol also has an important role for the brain synapses as well as in the immune system. In conditions of elevated low density lipoproteins (LDL), cholesterol often forms plaque deposits in the walls of arteries (atherosclerosis)


General
Type Natural, Steroid, Phenanthrene
Chemical_Nomenclature (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Canonical SMILES CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
InChI InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKey HVYWMOMLDIMFJA-DPAQBDIFSA-N
Other name(s) Cholesterin ; Cholesteryl alcohol ; Cholest-5-en-3beta-ol ; Cholestrin
________________________________________________________________________________________________
MW|386.65
Formula|C27H46O
CAS_number|57-88-5
PubChem|5997
UniChem|HVYWMOMLDIMFJA-DPAQBDIFSA-N
IUPHAR|
Wikipedia|Cholesterol

Target
Families | Cholesterol ligand of proteins in family: PC-sterol_acyltransferase

References:
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