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Substrate Report for: CurDD

Curcumin diethyl disuccinate, a prodrug of curcumin, enhances anti-proliferative effect of curcumin



General
Type: Drug, Pro-Drug, Natural_modified
Chemical_Nomenclature: 4,4'-((1E,6E)-3,5-Dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene)diethyl disuccinate
Canonical SMILES: CCOC(CCC(OC1=CC=C(C=C1OC)C=CC(=CC(C=CC2=CC(=C(C=C2)OC(CCC(OCC)=O)=O)OC)=O)O)=O)=O
InChI: InChI=1S/C33H36O12/c1-5-42-30(36)15-17-32(38)44-26-13-9-22(19-28(26)40-3)7-11-24(34)21-25(35)12-8-23-10-14-27(29(20-23)41-4)45-33(39)18-16-31(37)43-6-2/h7-14,19-21,34H,5-6,15-18H2,1-4H3
InChIKey: SKDNHNPKRBWDGR-UHFFFAOYSA-N
Other name(s): Curcumin diethyl disuccinate
MW: 624.64
Formula: C33H36O12
CAS_number:
PubChem:
IUPHAR:
Wikipedia:

Target families
CurDD ligand of proteins in family: BCHE, CMBL, Carb_B_Chordata
No structure

Protein target

References
Search PubMed for references concerning: CurDD

3 more
    Title: In Vitro Hepatic Metabolism of Curcumin Diethyl Disuccinate by Liver S9 from Different Animal Species
    Jithavech P, Ratnatilaka Na Bhuket P, Supasena W, Qiu G, Ye S, Wu J, Wong TW, Rojsitthisak P
    Ref: Front Pharmacol, 11:577998, 2020 : PubMed

            

    Title: Protective Effects of Curcumin Ester Prodrug, Curcumin Diethyl Disuccinate against H(2)O(2)-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells: Potential Therapeutic Avenues for Age-Related Macular Degeneration
    Muangnoi C, Sharif U, Ratnatilaka Na Bhuket P, Rojsitthisak P, Paraoan L
    Ref: Int J Mol Sci, 20:, 2019 : PubMed

            

    Title: Pharmacokinetics of Curcumin Diethyl Disuccinate, a Prodrug of Curcumin, in Wistar Rats
    Bangphumi K, Kittiviriyakul C, Towiwat P, Rojsitthisak P, Khemawoot P
    Ref: Eur J Drug Metab Pharmacokinet, 41:777, 2016 : PubMed