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Substrate Report for: MGDG

human-PNLIPRP2 adopt in solution an open lid conformation which creates a large cavity capable of accommodating the galactose polar head of galactolipids



General
Type: Acyl-Glycerol, Diacylglycerol, Galactolipid, Glycosydiacylglycerol, Dodecanoate
Chemical_Nomenclature: [2-octadecanoyloxy-3-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl] octadecanoate
Canonical SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(COC1C(C(C(C(O1)CO)O)O)O)OC(=O)CCCCCCCCCCCCCCCCC
InChI: InChI=1S/C45H86O10/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(47)52-36-38(37-53-45-44(51)43(50)42(49)39(35-46)55-45)54-41(48)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h38-39,42-46,49-51H,3-37H2,1-2H3/t38?,39-,42+,43+,44-,45-/m1/s1
InChIKey: DCLTVZLYPPIIID-XMGVTQGESA-N
Other name(s): Monogalactosyldiglyceride ; 1,2-Dsmgg ; 1,2-distearoylmonogalactosylglycerol ; AC1L4X2B ; CHEMBL234814 ; Mgdg (hydrogenated) (stearoyl) ; SCHEMBL2835125 ; 1,2-distearoylmonogalactosylglyceride ; 1,2-Di-O-dodecanoyl-3-O-beta-D-galactopyranosyl-sn-glycerol
MW: 618.84
Formula: C33H62O10
CAS_number: 41670-62-6
PubChem: 193820
IUPHAR:
Wikipedia: Galactolipid

Target families
MGDG ligand of proteins in family: Pancreatic_lipase, Lipase_3, Insect_lipase
No structure

Protein target

References
Search PubMed for references concerning: MGDG

9 more
    Title: Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2
    Amara S, Barouh N, Lecomte J, Lafont D, Robert S, Villeneuve P, de Caro A, Carriere F
    Ref: Biochimica & Biophysica Acta, 1801:508, 2010 : PubMed

            

    Title: Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation
    Eydoux C, Spinelli S, Davis TL, Walker JR, Seitova A, Dhe-Paganon S, de Caro A, Cambillau C, Carriere F
    Ref: Biochemistry, 47:9553, 2008 : PubMed

            

    Title: Human pancreatic lipase-related protein 2 is a galactolipase
    Sias B, Ferrato F, Grandval P, Lafont D, Boullanger P, de Caro A, Leboeuf B, Verger R, Carriere F
    Ref: Biochemistry, 43:10138, 2004 : PubMed