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Substrate Report for: MHET

product of hydrolysis of Polyethylene-terephthalate or HEMT model substrate. Polyethylene terephthalate is the most common thermoplastic polymer resin of the polyester family and is used in fibers for clothing, containers for liquids and foods. Degradation of PET using hydrolytic enzymes leads to the release of hydrolysis products such as BHET (bis(2-hydroxyethyl) terephthalate), MHET (mono-(2-hydroxyethyl) terephthalic acid), TPA (terephthalic acid) and EG (ethylene glycol)


General
Type Terephthalate, Phthalate, Benzoate
Chemical_Nomenclature 4-(2-hydroxyethoxycarbonyl)benzoic acid
Canonical SMILES C1=CC(=CC=C1C(=O)O)C(=O)OCCO
InChI InChI=1S/C10H10O5/c11-5-6-15-10(14)8-3-1-7(2-4-8)9(12)13/h1-4,11H,5-6H2,(H,12,13)
InChIKey BCBHDSLDGBIFIX-UHFFFAOYSA-N
Other name(s) 4-((2-Hydroxyethoxy)carbonyl)benzoic acid ; Mono(ethylene terephthalate) ; Ethylene glycol, cyclic ester with (C7-C11)dibasic acids ; AC1L5ATF ; ET ; C9C ; 4-[(2-hydroxyethoxy)carbonyl]benzoate ; 1,4-Benzenedicarboxylic acid, mono(2-hydroxyethyl) ester ; CTK0G1127 ; CHEBI:131701 ; CHEBI:131704
________________________________________________________________________________________________
MW|210.18
Formula|C10H10O5
CAS_number|1137-99-1
PubChem|174073, 22062452
UniChem|BCBHDSLDGBIFIX-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | MHET ligand of proteins in family: Polyesterase-lipase-cutinase, Tannase
Stucture | 2 structures: 7VVE, 6JTT
Protein | idesa-peth, idesa-mheth, thefu-q6a0i3, thefu-q6a0i4

References:
Search PubMed for references concerning: MHET

5 more
    Title: Characterization and engineering of a plastic-degrading aromatic polyesterase
    Austin HP, Allen MD, Donohoe BS, Rorrer NA, Kearns FL, Silveira RL, Pollard BC, Dominick G, Duman R and Beckham GT <11 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 115:E4350, 2018 : PubMed

            

    Title: New insights into the function and global distribution of polyethylene terephthalate (PET) degrading bacteria and enzymes in marine and terrestrial metagenomes
    Danso D, Schmeisser C, Chow J, Zimmermann W, Wei R, Leggewie C, Li X, Hazen T, Streit WR
    Ref: Applied Environmental Microbiology, 84:e2773, 2018 : PubMed

            

    Title: Structural insight into catalytic mechanism of PET hydrolase
    Han X, Liu W, Huang JW, Ma J, Zheng Y, Ko TP, Xu L, Cheng YS, Chen CC, Guo RT
    Ref: Nat Commun, 8:2106, 2017 : PubMed