Type : Neuromuscular Nondepolarizing Agents || Drug || Isoquinoline || Bisquaternary || Not A\/B H target
Chemical_Nomenclature : bis[3-[(1S)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]propyl] oct-4-enedioate dichloride
Canonical SMILES : C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)CCCOC(=O)CCC=CCCC(=O)OCCC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C(=C6)OC)OC)OC)OC)OC)C
InChI : InChI=1S\/C58H80N2O14\/c1-59(25-21-41-35-47(63-3)49(65-5)37-43(41)45(59)29-39-31-51(67-7)57(71-11)52(32-39)68-8)23-17-27-73-55(61)19-15-13-14-16-20-56(62)74-28-18-24-60(2)26-22-42-36-48(64-4)50(66-6)38-44(42)46(60)30-40-33-53(69-9)58(72-12)54(34-40)70-10\/h13-14,31-38,45-46H,15-30H2,1-12H3\/q+2\/b14-13+\/t45-,46-,59?,60?\/m1\/s1
InChIKey : ILVYCEVXHALBSC-OTBYEXOQSA-N
Other name(s) : BW B1090U Mivacron, Mivacron, BW B1090U
MW : 1029.26
Formula : C58H80N2O14
CAS_number :
PubChem :
UniChem :
Iuphar :
Families : BCHE
Title : Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism - McGehee_2000_Anesthesiology_93_510 |
Author(s) : McGehee DS , Krasowski MD , Fung DL , Wilson B , Gronert GA , Moss J |
Ref : Anesthesiology , 93 :510 , 2000 |
Abstract : McGehee_2000_Anesthesiology_93_510 |
ESTHER : McGehee_2000_Anesthesiology_93_510 |
PubMedSearch : McGehee_2000_Anesthesiology_93_510 |
PubMedID: 10910502 |
Title : Neuromuscular interactions between mivacurium and esmolol in rabbits - Kim_1998_Anaesthesia_53_140 |
Author(s) : Kim KS , Kim KH , Shin WJ , Yoo HK |
Ref : Anaesthesia , 53 :140 , 1998 |
Abstract : Kim_1998_Anaesthesia_53_140 |
ESTHER : Kim_1998_Anaesthesia_53_140 |
PubMedSearch : Kim_1998_Anaesthesia_53_140 |
PubMedID: 9534636 |
Title : [Muscle relaxants. New substances and neuromuscular monitoring] - Diefenbach_1997_Anaesthesist_46_3 |
Author(s) : Diefenbach C , Nigrovic V , Mellinghoff H , Buzello W |
Ref : Anaesthesist , 46 :3 , 1997 |
Abstract : Diefenbach_1997_Anaesthesist_46_3 |
ESTHER : Diefenbach_1997_Anaesthesist_46_3 |
PubMedSearch : Diefenbach_1997_Anaesthesist_46_3 |
PubMedID: 9082865 |
Title : [The clinical pharmacology of mivacurium] - Diefenbach_1997_Anaesthesist_46_385 |
Author(s) : Diefenbach C , Mellinghoff H |
Ref : Anaesthesist , 46 :385 , 1997 |
Abstract : Diefenbach_1997_Anaesthesist_46_385 |
ESTHER : Diefenbach_1997_Anaesthesist_46_385 |
PubMedSearch : Diefenbach_1997_Anaesthesist_46_385 |
PubMedID: 9245207 |
Title : [Esters and stereoisomers] - Nigrovic_1997_Anaesthesist_46_282 |
Author(s) : Nigrovic V , Diefenbach C , Mellinghoff H |
Ref : Anaesthesist , 46 :282 , 1997 |
Abstract : Nigrovic_1997_Anaesthesist_46_282 |
ESTHER : Nigrovic_1997_Anaesthesist_46_282 |
PubMedSearch : Nigrovic_1997_Anaesthesist_46_282 |
PubMedID: 9229981 |
Title : Plasma cholinesterase deficiency. - Dell_1996_J.Perianesth.Nurs_11_304 |
Author(s) : Dell DD , Kehoe C |
Ref : Journal of Perianesth Nurs , 11 :304 , 1996 |
Abstract : Dell_1996_J.Perianesth.Nurs_11_304 |
ESTHER : Dell_1996_J.Perianesth.Nurs_11_304 |
PubMedSearch : Dell_1996_J.Perianesth.Nurs_11_304 |
PubMedID: 8970294 |
Title : Pseudocholinesterase-mediated hydrolysis is superior to neostigmine for reversal of mivacurium-induced paralysis in vitro - Yang_1996_Anesthesiology_84_936 |
Author(s) : Yang HS , Goudsouzian N , Martyn JA |
Ref : Anesthesiology , 84 :936 , 1996 |
Abstract : Yang_1996_Anesthesiology_84_936 |
ESTHER : Yang_1996_Anesthesiology_84_936 |
PubMedSearch : Yang_1996_Anesthesiology_84_936 |
PubMedID: 8638849 |
Title : Mivacurium chloride--a comparative profile - Diffenbach_1995_Acta.Anaesthesiol.Scand.Suppl_106_23 |
Author(s) : Diffenbach C , Buzello W , Mellinghoff H |
Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :23 , 1995 |
Abstract : Diffenbach_1995_Acta.Anaesthesiol.Scand.Suppl_106_23 |
ESTHER : Diffenbach_1995_Acta.Anaesthesiol.Scand.Suppl_106_23 |
PubMedSearch : Diffenbach_1995_Acta.Anaesthesiol.Scand.Suppl_106_23 |
PubMedID: 8533540 |
Title : Mivacurium-induced prolonged neuromuscular block [see comments] - Sockalingam_1995_Br.J.Anaesth_74_234 |
Author(s) : Sockalingam I , Green DW |
Ref : British Journal of Anaesthesia , 74 :234 , 1995 |
Abstract : Sockalingam_1995_Br.J.Anaesth_74_234 |
ESTHER : Sockalingam_1995_Br.J.Anaesth_74_234 |
PubMedSearch : Sockalingam_1995_Br.J.Anaesth_74_234 |
PubMedID: 7696076 |
Title : Prolonged neuromuscular block associated with mivacurium [see comments] - Fox_1995_Br.J.Anaesth_74_237 |
Author(s) : Fox MH , Hunt PC |
Ref : British Journal of Anaesthesia , 74 :237 , 1995 |
Abstract : Fox_1995_Br.J.Anaesth_74_237 |
ESTHER : Fox_1995_Br.J.Anaesth_74_237 |
PubMedSearch : Fox_1995_Br.J.Anaesth_74_237 |
PubMedID: 7696077 |
Title : Comparison of the neuromuscular effects of mivacurium and suxamethonium in infants and children - Cook_1995_Acta.Anaesth.Scand.Supplementum_106_35 |
Author(s) : Cook DR , Gronert BJ , Woelfel SK |
Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :35 , 1995 |
Abstract : Cook_1995_Acta.Anaesth.Scand.Supplementum_106_35 |
ESTHER : Cook_1995_Acta.Anaesth.Scand.Supplementum_106_35 |
PubMedSearch : Cook_1995_Acta.Anaesth.Scand.Supplementum_106_35 |
PubMedID: 8533543 |
Title : Mivacurium in special patient groups. - Jones_1995_Acta.Anaesth.Scand.Supplementum_106_47 |
Author(s) : Jones RM |
Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :47 , 1995 |
Abstract : Jones_1995_Acta.Anaesth.Scand.Supplementum_106_47 |
ESTHER : Jones_1995_Acta.Anaesth.Scand.Supplementum_106_47 |
PubMedSearch : Jones_1995_Acta.Anaesth.Scand.Supplementum_106_47 |
PubMedID: 8533546 |
Title : Recovery of train-of-four after mivacurium - Brull_1995_Can.J.Anaesth_42_28 |
Author(s) : Brull SJ , Connelly NR , Silverman DG |
Ref : Canadian Journal of Anaesthesia , 42 :28 , 1995 |
Abstract : Brull_1995_Can.J.Anaesth_42_28 |
ESTHER : Brull_1995_Can.J.Anaesth_42_28 |
PubMedSearch : Brull_1995_Can.J.Anaesth_42_28 |
PubMedID: 7889581 |
Title : Changes in plasma cholinesterase activity and mivacurium neuromuscular block in response to normothermic cardiopulmonary bypass - Diefenbach_1995_Anesth.Analg_80_1088 |
Author(s) : Diefenbach C , Abel M , Rump AF , Grond S , Korb H , Buzello W |
Ref : Anesthesia & Analgesia , 80 :1088 , 1995 |
Abstract : Diefenbach_1995_Anesth.Analg_80_1088 |
ESTHER : Diefenbach_1995_Anesth.Analg_80_1088 |
PubMedSearch : Diefenbach_1995_Anesth.Analg_80_1088 |
PubMedID: 7762834 |
Title : Enzymatic antagonism of mivacurium-induced neuromuscular blockade by human plasma cholinesterase - Naguib_1995_Anesthesiology_83_694 |
Author(s) : Naguib M , Daoud W , El-Gammal M , Ammar A , Turkistani A , Selim M , Altamimi W , Sohaibani MO |
Ref : Anesthesiology , 83 :694 , 1995 |
Abstract : Naguib_1995_Anesthesiology_83_694 |
ESTHER : Naguib_1995_Anesthesiology_83_694 |
PubMedSearch : Naguib_1995_Anesthesiology_83_694 |
PubMedID: 7574048 |
Title : Spontaneous recovery or evoked reversal of neuromuscular block - Mirakhur_1995_Acta.Anaesthesiol.Scand.Suppl_106_62 |
Author(s) : Mirakhur RK |
Ref : Acta Anaesthesiologica Scandinavica Supplementum , 106 :62 , 1995 |
Abstract : Mirakhur_1995_Acta.Anaesthesiol.Scand.Suppl_106_62 |
ESTHER : Mirakhur_1995_Acta.Anaesthesiol.Scand.Suppl_106_62 |
PubMedSearch : Mirakhur_1995_Acta.Anaesthesiol.Scand.Suppl_106_62 |
PubMedID: 8533549 |
Title : Edrophonium increases mivacurium concentrations during constant mivacurium infusion, and large doses minimally antagonize paralysis [see comments] - Hart_1995_Anesthesiology_82_912 |
Author(s) : Hart PS , Wright PM , Brown R , Lau M , Sharma ML , Miller RD , Gruenke L , Fisher DM |
Ref : Anesthesiology , 82 :912 , 1995 |
Abstract : Hart_1995_Anesthesiology_82_912 |
ESTHER : Hart_1995_Anesthesiology_82_912 |
PubMedSearch : Hart_1995_Anesthesiology_82_912 |
PubMedID: 7717563 |
Title : Mivacurium apnoea [letter\; comment] - |
Author(s) : Lightman DJ |
Ref : Anaesthesia , 49 :835 , 1994 |
PubMedID: 7978163 |
Title : Mivacurium. A review of its pharmacology and therapeutic potential in general anaesthesia - Frampton_1993_Drugs_45_1066 |
Author(s) : Frampton JE , McTavish D |
Ref : Drugs , 45 :1066 , 1993 |
Abstract : Frampton_1993_Drugs_45_1066 |
ESTHER : Frampton_1993_Drugs_45_1066 |
PubMedSearch : Frampton_1993_Drugs_45_1066 |
PubMedID: 7691494 |
Title : Clinical pharmacology of mivacurium chloride: a review - Basta_1992_J.Clin.Anesth_4_153 |
Author(s) : Basta SJ |
Ref : Journal of Clinical Anesthesia , 4 :153 , 1992 |
Abstract : Basta_1992_J.Clin.Anesth_4_153 |
ESTHER : Basta_1992_J.Clin.Anesth_4_153 |
PubMedSearch : Basta_1992_J.Clin.Anesth_4_153 |
PubMedID: 1373287 |
Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35 |
Author(s) : Lockridge O |
Ref : Pharmacol Ther , 47 :35 , 1990 |
Abstract : Lockridge_1990_Pharmacol.Ther_47_35 |
ESTHER : Lockridge_1990_Pharmacol.Ther_47_35 |
PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35 |
PubMedID: 2195556 |
Gene_locus related to this paper: human-BCHE |