Naproxen-Methyl-Ester
General
Type : Profen prodrug || Pro-Drug || Drug || Naphthalen || Propionate
Chemical_Nomenclature : methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
Canonical SMILES : CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OC
InChI : InChI=1S\/C15H16O3\/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11\/h4-10H,1-3H3\/t10-\/m0\/s1
InChIKey : ZFYFBPCRUQZGJE-JTQLQIEISA-N
Other name(s) : Naproxen Methyl Ester, (S)-Methyl 2-(6-methoxynaphthalen-2-yl)propanoate, (S)-Naproxen Methyl Ester, Methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate, SCHEMBL505819, ZINC21986245
Target
Families : 6_AlphaBeta_hydrolase, Hormone-sensitive_lipase_like
References (6)
| Title : Biochemical and Structural Characterization of a novel thermophilic esterase EstD11 provide catalytic insights for the HSL family - Miguel-Ruano_2021_Comput.Struct.Biotechnol.J_19_1214 |
| Author(s) : Miguel-Ruano V , Rivera I , Rajkovic J , Knapik K , Torrado A , Otero JM , Beneventi E , Becerra M , Sanchez-Costa M , Hidalgo A , Berenguer J , Gonzalez-Siso MI , Cruces J , Rua ML , Hermoso JA |
| Ref : Comput Struct Biotechnol J , 19 :1214 , 2021 |
| Abstract : Miguel-Ruano_2021_Comput.Struct.Biotechnol.J_19_1214 |
| ESTHER : Miguel-Ruano_2021_Comput.Struct.Biotechnol.J_19_1214 |
| PubMedSearch : Miguel-Ruano_2021_Comput.Struct.Biotechnol.J_19_1214 |
| PubMedID: 33680362 |
| Gene_locus related to this paper: 9delt-EstD11 |
| Title : Immobilization of Candida rugosa lipase on glass beads for enantioselective hydrolysis of racemic naproxen methyl ester - Yilmaz_2011_Bioresour.Technol_102_499 |
| Author(s) : Yilmaz E , Can K , Sezgin M , Yilmaz M |
| Ref : Bioresour Technol , 102 :499 , 2011 |
| Abstract : Yilmaz_2011_Bioresour.Technol_102_499 |
| ESTHER : Yilmaz_2011_Bioresour.Technol_102_499 |
| PubMedSearch : Yilmaz_2011_Bioresour.Technol_102_499 |
| PubMedID: 20846857 |
| Gene_locus related to this paper: canru-1lipa |
| Title : Efficient production of (S)-naproxen with (R)-substrate recycling using an overexpressed carboxylesterase BsE-NP01 - Liu_2010_Appl.Biochem.Biotechnol_162_1574 |
| Author(s) : Liu X , Xu JH , Pan J , Zhao J |
| Ref : Appl Biochem Biotechnol , 162 :1574 , 2010 |
| Abstract : Liu_2010_Appl.Biochem.Biotechnol_162_1574 |
| ESTHER : Liu_2010_Appl.Biochem.Biotechnol_162_1574 |
| PubMedSearch : Liu_2010_Appl.Biochem.Biotechnol_162_1574 |
| PubMedID: 20237863 |
| Gene_locus related to this paper: bacsu-cbxnp |
| Title : Comparison and functional characterisation of three homologous intracellular carboxylesterases of Bacillus subtilis - Droge_2005_J.Mol.Catal.B.Enzym_32_261 |
| Author(s) : Droge MJ , Bos R , Boersma YL , Quax WJ |
| Ref : J Mol Catal B Enzym , 32 :261 , 2005 |
| Abstract : Droge_2005_J.Mol.Catal.B.Enzym_32_261 |
| ESTHER : Droge_2005_J.Mol.Catal.B.Enzym_32_261 |
| PubMedSearch : Droge_2005_J.Mol.Catal.B.Enzym_32_261 |
| PubMedID: |
| Gene_locus related to this paper: bacsu-cbxnp , bacsu-ybfk |
| Title : Investigation of lipase-catalysed hydrolysis of naproxen methyl ester: use of NMR spectroscopy methods to study substrate-enzyme interaction - Cernia_2002_Bioorg.Chem_30_276 |
| Author(s) : Cernia E , Delfini M , Di Cocco E , Palocci C , Soro S |
| Ref : Bioorg Chem , 30 :276 , 2002 |
| Abstract : Cernia_2002_Bioorg.Chem_30_276 |
| ESTHER : Cernia_2002_Bioorg.Chem_30_276 |
| PubMedSearch : Cernia_2002_Bioorg.Chem_30_276 |
| PubMedID: 12392706 |
| Title : Paralogous gene analysis reveals a highly enantioselective 1,2-O-isopropylideneglycerol caprylate esterase of Bacillus subtilis - Droge_2001_Eur.J.Biochem_268_3332 |
| Author(s) : Droge MJ , Bos R , Quax WJ |
| Ref : European Journal of Biochemistry , 268 :3332 , 2001 |
| Abstract : Droge_2001_Eur.J.Biochem_268_3332 |
| ESTHER : Droge_2001_Eur.J.Biochem_268_3332 |
| PubMedSearch : Droge_2001_Eur.J.Biochem_268_3332 |
| PubMedID: 11389736 |
| Gene_locus related to this paper: bacsu-cbxnp |