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Substrate Report for: Prasugrel

Prasugrel binds to the platelet receptor for adenosine diphosphate (ADP). It is an inhibitor of platelet aggregation



General
Type: Drug, Not A/B H target, Acetate, Cyclopropyl
Chemical_Nomenclature: [5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-2-yl] acetate
Canonical SMILES: CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4
InChI: InChI=1S/C20H20FNO3S/c1-12(23)25-18-10-14-11-22(9-8-17(14)26-18)19(20(24)13-6-7-13)15-4-2-3-5-16(15)21/h2-5,10,13,19H,6-9,11H2,1H3
InChIKey: DTGLZDAWLRGWQN-UHFFFAOYSA-N
Other name(s): Effient ; Efient ; CS-747
MW: 373.4
Formula: C20H20FNO3S
CAS_number: 150322-43-3
PubChem: 6918456
IUPHAR:
Wikipedia:

Target families
Prasugrel ligand of proteins in family: Carb_B_Chordata, Arylacetamide_deacetylase
No structure

Protein target

References
Search PubMed for references concerning: Prasugrel

1 more
    Title: Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog
    Kurokawa T, Fukami T, Yoshida T, Nakajima M
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 44:409, 2016 : PubMed

            

    Title: A comparison of the metabolism of clopidogrel and prasugrel
    Laizure SC, Parker RB
    Ref: Expert Opin Drug Metab Toxicol, 6:1417, 2010 : PubMed

            

    Title: The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2
    Williams ET, Jones KO, Ponsler GD, Lowery SM, Perkins EJ, Wrighton SA, Ruterbories KJ, Kazui M, Farid NA
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 36:1227, 2008 : PubMed