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Substrate Report for: Retinol-palmitate

Retinyl Palmitate is a naturally-occurring phenyl analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. As the most common form of vitamin A taken for dietary supplementation, retinyl palmitate binds to and activates retinoid receptors, thereby inducing cell differentiation and decreasing cell proliferation. PNPLA3 (patatin not a/b hydrolase) has also retinyl-palmitate lipase activity



General
Type: Natural, Retinol ester, Hexadecanoate
Chemical_Nomenclature: [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] hexadecanoate
Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(CCCC1(C)C)C
InChI: InChI=1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
InChIKey: VYGQUTWHTHXGQB-FFHKNEKCSA-N
Other name(s): Vitamin A palmitate ; retinyl palmitate ; Retinol palmitate ; Retinol, hexadecanoate ; CHEMBL1675 ; CHEBI:17616 ; SCHEMBL41649
MW: 524.9
Formula: C38H62O2
CAS_number: 79-81-2
PubChem: 11699609, 5280531
IUPHAR:
Wikipedia:

Target families
No structure

Protein target

References
Search PubMed for references concerning: Retinol-palmitate

1 more
    Title: Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions
    Reboul E, Berton A, Moussa M, Kreuzer C, Crenon I, Borel P
    Ref: Biochimica & Biophysica Acta, 1761:4, 2006 : PubMed

            

    Title: Isolation and characterization of a microsomal acid retinyl ester hydrolase
    Linke T, Dawson H, Harrison EH
    Ref: Journal of Biological Chemistry, 280:23287, 2005 : PubMed

            

    Title: Carotenol fatty acid esters: easy substrates for digestive enzymes?
    Breithaupt DE, Bamedi A, Wirt U
    Ref: Comparative Biochemistry & Physiology B Biochem Mol Biol, 132:721, 2002 : PubMed