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Substrate Report for: Tenofovir-alafenamide

A prodrug for tenofovir (HIV-1 reverse transcriptase inhibitor), used in combination therapy for the treatment of HIV-1 infection. L-alanine derivative, a phosphoramidate ester



General
Type: Drug, Aminopurin, Propionate
Chemical_Nomenclature: propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate
Canonical SMILES: CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3
InChI: InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1
InChIKey: LDEKQSIMHVQZJK-CAQYMETFSA-N
Other name(s): Tenofovir alafenamide ; GS-7340 ; UNII-J4414G3BUK ; J4414G3BUK
MW: 476.5
Formula: C21H29N6O5P
CAS_number: 379270-37-8
PubChem: 9574768
IUPHAR:
Wikipedia:

Target families
Tenofovir-alafenamide ligand of proteins in family: Carboxypeptidase_S10, Carb_B_Chordata
No structure

Protein target

References
Search PubMed for references concerning: Tenofovir-alafenamide

3 more
    Title: Contributions of Cathepsin A and Carboxylesterase 1 to the hydrolysis of Tenofovir Alafenamide in the Human Liver, and the Effect of CES1 Genetic Variation on Tenofovir Alafenamide Hydrolysis
    Li J, Shi J, Xiao J, Tran L, Wang X, Zhu HJ
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, :, 2021 : PubMed

            

    Title: Activation of Tenofovir Alafenamide and Sofosbuvir in the Human Lung and Its Implications in the Development of Nucleoside/Nucleotide Prodrugs for Treating SARS-CoV-2 Pulmonary Infection
    Li J, Liu S, Shi J, Zhu HJ
    Ref: Pharmaceutics, 13:, 2021 : PubMed

            

    Title: Implications of Efficient Hepatic Delivery by Tenofovir Alafenamide (GS-7340) for Hepatitis B Virus Therapy
    Murakami E, Wang T, Park Y, Hao J, Lepist EI, Babusis D, Ray AS
    Ref: Antimicrobial Agents & Chemotherapy, 59:3563, 2015 : PubMed