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Substrate Report for: Tween-20

Model substrate for lipases or phospholipase. but also used as excipient, surface-active agent (detergent, emulsifier). Used as model substrate for TLE1 and TLE2 secreted by the bacterial type VI secretion system (T6SS)


General
Type Polysorbate, Detergent, Dodecanoate
Chemical_Nomenclature 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
Canonical SMILES CCCCCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO
InChI InChI=1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3
InChIKey HMFKFHLTUCJZJO-UHFFFAOYSA-N
Other name(s) Tween20 ; Tween 20 ; Polysorbate 20 ; Polysorbate (INN) ; Polysorbate ; Polyoxyethylene sorbitan monolaurate
________________________________________________________________________________________________
MW|522.66
Formula|C26H50O10
CAS_number|9005-64-5
PubChem|443314
UniChem|HMFKFHLTUCJZJO-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Tween-20 ligand of proteins in family: Duf_2235, Lipase_3

References:
Search PubMed for references concerning: Tween-20
    Title: Hydrolysis of Polysorbate 20 and 80 by a Range of Carboxylester Hydrolases
    McShan AC, Kei P, Ji JA, Kim DC, Wang YJ
    Ref: PDA J Pharm Sci Technol, 70:332, 2016 : PubMed

            

    Title: Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors
    Russell AB, LeRoux M, Hathazi K, Agnello DM, Ishikawa T, Wiggins PA, Wai SN, Mougous JD
    Ref: Nature, 496:508, 2013 : PubMed