Vicagrel
General
Type : Not A\/B H target || Drug || Pyridine || Acetate
Chemical_Nomenclature : methyl (2S)-2-(2-acetyloxy-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate
Canonical SMILES : CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3Cl)C(=O)OC
InChI : InChI=1S\/C18H18ClNO4S\/c1-11(21)24-16-9-12-10-20(8-7-15(12)25-16)17(18(22)23-2)13-5-3-4-6-14(13)19\/h3-6,9,17H,7-8,10H2,1-2H3\/t17-\/m0\/s1
InChIKey : GNHHCBSBCDGWND-KRWDZBQOSA-N
Other name(s) : CHEMBL2042273, SCHEMBL12438770, ZINC84654546, AJ-126334
MW : 379.85
Formula : C18H18ClNO4S
CAS_number :
PubChem :
UniChem :
Iuphar :
Target
Families : Arylacetamide_deacetylase, Carb_B_Chordata
References (3)
| Title : Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation - Jia_2019_Biomed.Pharmacother_115_108906 |
| Author(s) : Jia YM , Ge PX , Zhou H , Ji JZ , Tai T , Gu TT , Zhu T , Li YF , Mi QY , Huang BB , Xie HG |
| Ref : Biomed Pharmacother , 115 :108906 , 2019 |
| Abstract : Jia_2019_Biomed.Pharmacother_115_108906 |
| ESTHER : Jia_2019_Biomed.Pharmacother_115_108906 |
| PubMedSearch : Jia_2019_Biomed.Pharmacother_115_108906 |
| PubMedID: 31060007 |
| Title : Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans - Jiang_2017_Front.Pharmacol_8_846 |
| Author(s) : Jiang J , Chen X , Zhong D |
| Ref : Front Pharmacol , 8 :846 , 2017 |
| Abstract : Jiang_2017_Front.Pharmacol_8_846 |
| ESTHER : Jiang_2017_Front.Pharmacol_8_846 |
| PubMedSearch : Jiang_2017_Front.Pharmacol_8_846 |
| PubMedID: 29209217 |
| Title : Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase - Shimizu_2014_Drug.Metab.Dispos_42_1103 |
| Author(s) : Shimizu M , Fukami T , Nakajima M , Yokoi T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :1103 , 2014 |
| Abstract : Shimizu_2014_Drug.Metab.Dispos_42_1103 |
| ESTHER : Shimizu_2014_Drug.Metab.Dispos_42_1103 |
| PubMedSearch : Shimizu_2014_Drug.Metab.Dispos_42_1103 |
| PubMedID: 24751575 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |