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Torpedo_number Report for: 119
9acar-r4zgq0
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G119S
nat
OP-resistance
chlorpyrifos resistant strain
Cassanelli_2015_Biol.Control_90_75
anoga-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G119S
nat
OP-resistance
Mutant are resistant to OP insecticides, This mutation occurred twice in the C. pipiens complex and once in A. Gambiae
Weill_2003_Nature_423_136
G119S
nat
OP-resistance
Mutant are resistant to OP insecticides,Two mutations at the first base (G/T) and (G/C) at the second base in Anopheles albimanus
Liebman_2015_Malar.J_14_74
aphgo-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G221A
nat
OP-resistance
OP resistance
Lokeshwari_2016_J.Econ.Entomol_109_887
boomi-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G142S
sdm
OP-resistance
May Contribute to OP-resistance
Temeyer_2019_J.Med.Entomol_56_1318
bunfa-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G119H/
Y121Q/
S122T
sdm
OP-hydrolase
OP-hydrolase but 4 fold less kcat/Km for ACh than WT
Poyot_2006_Biochim.Biophys.Acta_1764_1470
colho-E3aest7
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G137D
nat
OP-resistance
Carvalho_2006_Vet.Parasitol_140_344
G137D
nat
OP-resistance
Carvalho_2009_Med.Vet.Entomol_23_86
G137D
nat
OP-resistance
da Silva_2011_Vet.Parasitol_177_190
culpi-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G119S
nat
OP-resistance
Mutant are resistant to OP insecticides, This mutation occurred twice in the C. pipiens complex and once in A. Gambiae
Weill_2003_Nature_423_136
G119S
nat
OP-resistance
G119S substitution in resistant C. vishnui mosquitoes in china
Alout_2007_J.Med.Entomol_44_463
G119S
nat
OP-resistance
G247S substitution in resistant mosquitoes in china
Zhao_2014_PLoS.One_9_e952607
G119S
nat
OP-resistance
malathion resistance in Culex quinquefasciatus Say populations in Malaysia
Low_2013_Pest.Manag.Sci_69_1362
G119S
nat
OP-resistance
resistance in Culex pipiens field populations from north-eastern areas of Italy
Toma_2011_Pest.Manag.Sci_67_100
drome-EST23aes07
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G137D
sdm
Pyrethroids hydrolysis
search for Pyrethroids hydrolysis activities
Heidari_2005_Insect.Biochem.Mol.Biol_35_597
human-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G122A
sdm
Oxyanion hole
Steric hindrance of acyl pocket
Ordentlich_1998_J.Biol.Chem_273_19509
human-BCHE
:
(
kinetic parameters
)
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G117H/
E197Q
sdm
Search for phosphotriesterase activity
Phosphotriesterase activity
Millard_1998_Biochemistry_37_237
PYGTP281-284EPYNGTA/
G117H
sdm
Search for phosphotriesterase activity
Phosphotriesterase activity Hydrolysis of OP
Hester_2019_Chem.Res.Toxicol_32_1801
G117H
kin
sdm
Search for phosphotriesterase activity
Phosphotriesterase activity Hydrolysis of OP Hydrolyses VX but not Soman
Lockridge_1997_Biochemistry_36_786
,
Millard_1995_Biochemistry_34_15925
,
Millard_1998_Biochemistry_37_237
G117H
kin
sdm
OP-resistance
Preserve activity, increase resistance to OP
Broomfield_1995_5th.ChE.Meeting.Madras__169
G117R
sdm
OP-resistance
Not as strong resistance as G117H
Zhang_2012_J.Pharmacol.Exp.Ther_343_673
G117N
sdm
OP-resistance
Not as strong resistance as G117H
Zhang_2012_J.Pharmacol.Exp.Ther_343_673
G117K
sdm
Search for phosphotriesterase activity
Phosphotriesterase activity OP sensitive
Millard_1995_Biochemistry_34_15925
,
Millard_1998_Biochemistry_37_237
G116A/
G117D
kin
sdm
Oxyanion hole
no activity
Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
G117E
kin
sdm
Oxyanion hole
Lower kcat and kcat/Km
Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
G117E
kin
sdm
Search for phosphotriesterase activity
Phosphotriesterase activity OP sensitive
Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1
G117C
sdm
Search for phosphotriesterase activity
Phosphotriesterase activity OP sensitive
Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1
G117Y
sdm
Search for phosphotriesterase activity
Phosphotriesterase activity OP sensitive
Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1
G117S
sdm
Search for phosphotriesterase activity
Phosphotriesterase activity OP sensitive
Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1
G117D
kin
sdm
Oxyanion hole
lowest kcat
Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
G117D
kin
sdm
Search for phosphotriesterase activity
Phosphotriesterase activity OP sensitive
Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1
human-CES1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G143E
nat, sdm
Expression
Low activity or expression
Zhu_2008_Am.J.Hum.Genet_82_1241
G143E
nat, sdm
Expression
increased clopidogrel active metabolite levels and greater clopidogrel response
Lewis_2013_Pharmacogenet.Genomics_23_1
G143E
nat, sdm
Expression
activation of the antiviral prodrug oseltamivir is impaired
Zhu_2009_Drug.Metab.Dispos_37_264
G143E
nat, sdm
Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender
Shi_2016_Biochem.Pharmacol_119_76
G143E
nat, sdm
Enalapril activation is affected by the CES1 genetic polymorphism G143E (rs71647871)
Ikonnikova_2022_J.Pers.Med_12_580
hyaaz-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G119S
nat
OP-resistance
Mutation orthologous to insecticide resistant mutation in other species
Major_2019_Evol.Appl_13_620
luccu-E3aest7
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G137D
sdm, nat
OP-resistance
search for OP hydrolase and MCE activities
Heidari_2004_Insect.Biochem.Mol.Biol_34_353
G137D
sdm, nat
Pyrethroids hydrolysis
search for Pyrethroids hydrolysis activities
Heidari_2005_Insect.Biochem.Mol.Biol_35_597
G137D
sdm, nat
Pyrethroids hydrolysis
Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases
Devonshire_2007_Insect.Biochem.Mol.Biol_37_891
G137D
sdm, nat
OP-resistance
Mutant are resistant to OP insecticides, G137D is responsible for loss of E3's carboxylesterase activity,acquisition of OP hydrolase activity (E3-Rdz Diazinon and diethyl OP)
Newcomb_1997_Proc.Natl.Acad.Sci.U.S.A_94_7464
G137D
sdm, nat
OP-resistance
2 G137D and 2 W251L haplotypes found in natural populations
Newcomb_2005_J.Mol.Evol_60_207
G137E
sdm
OP-resistance
search for OP hydrolase and MCE activities
Heidari_2004_Insect.Biochem.Mol.Biol_34_353
G137E
sdm
Pyrethroids hydrolysis
search for Pyrethroids hydrolysis activities
Heidari_2005_Insect.Biochem.Mol.Biol_35_597
G137E
sdm
Pyrethroids hydrolysis
Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases
Devonshire_2007_Insect.Biochem.Mol.Biol_37_891
G137H
sdm
OP-resistance
search for OP hydrolase and MCE activities
Heidari_2004_Insect.Biochem.Mol.Biol_34_353
G137H
sdm
Pyrethroids hydrolysis
search for Pyrethroids hydrolysis activities
Heidari_2005_Insect.Biochem.Mol.Biol_35_597
G137H
sdm
Pyrethroids hydrolysis
Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases
Devonshire_2007_Insect.Biochem.Mol.Biol_37_891
G137R
sdm
OP-resistance
search for OP hydrolase and MCE activities
Heidari_2004_Insect.Biochem.Mol.Biol_34_353
G137R
sdm
Pyrethroids hydrolysis
search for Pyrethroids hydrolysis activities
Heidari_2005_Insect.Biochem.Mol.Biol_35_597
G137R
sdm
Pyrethroids hydrolysis
Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases
Devonshire_2007_Insect.Biochem.Mol.Biol_37_891
G137D/
Y148F
sdm
OP-resistance
search for OP hydrolase and MCE activities
Heidari_2004_Insect.Biochem.Mol.Biol_34_353
G137D/
Y148F
sdm
Pyrethroids hydrolysis
search for Pyrethroids hydrolysis activities
Heidari_2005_Insect.Biochem.Mol.Biol_35_597
G137D/
Y148F
sdm
Pyrethroids hydrolysis
Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases
Devonshire_2007_Insect.Biochem.Mol.Biol_37_891
G137D/
W251L
sdm
OP-resistance
search for OP hydrolase and MCE activities
Heidari_2004_Insect.Biochem.Mol.Biol_34_353
G137D/
W251L
sdm
Pyrethroids hydrolysis
search for Pyrethroids hydrolysis activities
Heidari_2005_Insect.Biochem.Mol.Biol_35_597
G137D/
W251L
sdm
Pyrethroids hydrolysis
Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases
Devonshire_2007_Insect.Biochem.Mol.Biol_37_891
musdo-EST23aes07
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G137D
nat
OP-resistance
Mutant are resistant to OP insecticides, acquisition of OP hydrolase activity
Claudianos_1999_Insect.Biochem.Mol.Biol_29_675
nillu-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G119S
nat
OP-resistance
associated in chlorpyrifos resistant strain
Zhang_2017_Insect.Mol.Biol_26_453
G119A
nat
OP-resistance
associated in carbofuran resistant strain (CAS)
Kwon_2012_Pestic.Biochem.Physiol_103_94
phlpp-m1f887
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G119S
sdm
OP-resistance
Mutation orthologous to insecticide resistant mutation in other species
Temeyer_2014_Parasit.Vectors_7_577
tetur-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G119S/
A280T/
F331W
nat
OP-resistance
Insecticide resistance, amplified allele
Kwon_2012_Insect.Biochem.Mol.Biol_42_212
G119S/
A280T
nat
OP-resistance
Insecticide resistance, amplified allele
Kwon_2012_Insect.Biochem.Mol.Biol_42_212
G119S/
F331W
nat
OP-resistance
Insecticide resistance, amplified allele
Kwon_2012_Insect.Biochem.Mol.Biol_42_212
G119S
nat
OP-resistance
Insecticide resistance
Kwon_2010_Pestic.Biochem.Physiol_96_36
G119S
nat
OP-resistance
Insecticide resistance, amplified allele
Kwon_2010_Insect.Mol.Biol_19_195
G119S
nat
OP-resistance
Insecticide resistance, amplified allele
Kwon_2012_Insect.Biochem.Mol.Biol_42_212
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Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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