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Torpedo_number Report for: 129

bacdo-ACHE
MutationKin.TypeEvaluation systemEffectReference
I214V/
G488S/
Q643R
 natOP-resistanceOP-resistance (Fenitrothion)Hsu_2006_Insect.Biochem.Mol.Biol_36_396
I214V natOP-resistanceOP-resistance (Fenitrothion)Hsu_2006_Insect.Biochem.Mol.Biol_36_396

bacol-ACHE
MutationKin.TypeEvaluation systemEffectReference
I214V natOP-resistanceOP-resistance (omethoate)Vontas_2002_Insect.Mol.Biol_11_329
I214V natNatural mutationNot found associated with resistanceKakani_2008_Insect.Biochem.Mol.Biol_38_781
I214V/
G488S
 natOP-resistanceOP-resistance (omethoate)Vontas_2002_Insect.Mol.Biol_11_329

drome-ACHE
MutationKin.TypeEvaluation systemEffectReference
I199A sdmInsecticide sensitivityBoublik_2002_Protein.Eng_15_43
I199W sdmInsecticide sensitivityBoublik_2002_Protein.Eng_15_43
I199V sdmInsecticide sensitivityBoublik_2002_Protein.Eng_15_43
I199V sdmInsecticide sensitivityMenozzi_2004_BMC.Evol.Biol_4_4
I199V sdmInsecticide sensitivityChen_2001_Insect.Biochem.Mol.Biol_31_805
I199V sdmOP-resistanceOP-resistance lower than multiple mutations,mut found in Saltillo strain together with F115S G303A F368YMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
I199T sdmInsecticide sensitivityBoublik_2002_Protein.Eng_15_43
I199R sdmInsecticide sensitivityBoublik_2002_Protein.Eng_15_43
I199K sdmInsecticide sensitivityBoublik_2002_Protein.Eng_15_43
I199G sdmInsecticide sensitivityBoublik_2002_Protein.Eng_15_43
I199E sdmInsecticide sensitivityBoublik_2002_Protein.Eng_15_43
F115S/
I199V
 sdmOP-resistanceOP-resistance lower than multiple,mut found in Saltillo strain together with I199V G303A F368YMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
F115S/
I199V/
G303A
 sdmOP-resistanceOP-resistance lower than multiple,mut found in Saltillo strain together with I199V G303A F368YMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
F115S/
I199V/
F368Y
 sdmOP-resistanceOP-resistance lower than multiple,mut found in Saltillo strain together with I199V G303A F368YMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
F115S/
I199V/
G303A/
F368Y
 natNatural mutationSaltillo strain OP-resistanceMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
I199V/
G303A
 sdm, natOP-resistanceBygdia strain and sdm OP-resistanceMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
I199V/
G303A
 sdm, natOP-resistanceBygdia strain and sdm OP-resistanceMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_592
I199T/
G303A
 natOP-resistancePierrefeu strain OP-resistanceMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
I199T/
G303A
 natOP-resistancePierrefeu strain OP-resistanceMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_592
I199V/
F368Y
 sdmOP-resistanceTwo mutations found in Saltillo strainMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
I199V/
G303A/
F368Y
 sdmOP-resistanceThree mutations found in OP-resistant Saltillo strainMutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922

human-ACHE : (kinetic parameters)
MutationKin.TypeEvaluation systemEffectReference
V132AkinsdmBack door hypothesisV132A reduce steric hindrance at the rim of the hypothetical back door,No effectKronman_1994_J.Biol.Chem_269_27819
V132KkinsdmBack door hypothesisV132K introduce a charge and should block the door, 6X increase of Km for ATc but not for TB through interaction with W86Kronman_1994_J.Biol.Chem_269_27819

human-BCHE : (kinetic parameters)
MutationKin.TypeEvaluation systemEffectReference
V127DkinsdmBack door hypothesisNo changes in Km BTCh or Ki of inhibitors testedLoewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423

luccu-ACHE
MutationKin.TypeEvaluation systemEffectReference
I199V sdmInsecticide sensitivityChen_2001_Insect.Biochem.Mol.Biol_31_805
I199T sdmInsecticide sensitivityChen_2001_Insect.Biochem.Mol.Biol_31_805
F115S/
I199V/
F368Y
 sdmOP-resistanceChen_2001_Insect.Biochem.Mol.Biol_31_805
I199V/
F368Y
 sdmOP-resistanceChen_2001_Insect.Biochem.Mol.Biol_31_805
I199V/
G303A/
F368Y
 sdmOP-resistanceChen_2001_Insect.Biochem.Mol.Biol_31_805

torma-ACHE
MutationKin.TypeEvaluation systemEffectReference
V129K sdmBack door hypothesisNo effect of mutationFaerman_1996_FEBS.Lett_386_65
V129R sdmBack door hypothesisNo effect of mutationFaerman_1996_FEBS.Lett_386_65
V129R/
C231S
 sdmBack door hypothesisNo effect of mutationFaerman_1996_FEBS.Lett_386_65
V129K/
C231S
 sdmBack door hypothesisNo effect of mutationFaerman_1996_FEBS.Lett_386_65

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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