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Torpedo_number Report for: 131
boomi-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
D188G/
E196G/
V331A/
F390S
nat
p.Asp188Gly/Glu196Gly/Val331Ala/Phe390Ser OP-resistance
Found in OP-resistant strain Tuxpan insensitive to paraoxon
Temeyer_2010_Vet.Parasitol_172_114
human-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
D134H/
Y337A
sdm
Oxime interaction
Cochran_2011_J.Biol.Chem_286_29718
D134H/
F338A
sdm
Oxime interaction
Cochran_2011_J.Biol.Chem_286_29718
D134H
nat
Natural mutation
ACHE:G/C Asp134His snp
Valle_2011_J.Pharmacol.Exp.Ther_338_125
D134H
nat
Oxime interaction
no effect
Cochran_2011_J.Biol.Chem_286_29718
D134H/
R136Q
sdm
Stability
ACHE:G/C R136Q was introduced to revert effect of natural snp D134H
Valle_2011_J.Pharmacol.Exp.Ther_338_125
pluxy-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
D131G
nat
OP-resistance
D131G A201S A441G (D229G, A298S,A324G) found together in resistant strains but G227A likely to be important
Lee_2007_Biochem.Biophys.Res.Commun_353_591
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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